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Book

Drug Bioavailability

Gary Price  1 , Deven A. Patel  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Drug Bioavailability

Gary Price et al.
Free Books & Documents

Excerpt

Bioavailability refers to the extent a substance or drug becomes completely available to its intended biological destination(s). More accurately, bioavailability is a measure of the rate and fraction of the initial dose of a drug that successfully reaches either; the site of action or the bodily fluid domain from which the drug's intended targets have unimpeded access.

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Conflict of interest statement

Disclosure: Gary Price declares no relevant financial relationships with ineligible companies.

Disclosure: Deven Patel declares no relevant financial relationships with ineligible companies.

References

    1. Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221-230. - PubMed
    1. Herkenne C, Alberti I, Naik A, Kalia YN, Mathy FX, Préat V, Guy RH. In vivo methods for the assessment of topical drug bioavailability. Pharm Res. 2008 Jan;25(1):87-103. - PMC - PubMed
    1. Chow SC. Bioavailability and Bioequivalence in Drug Development. Wiley Interdiscip Rev Comput Stat. 2014;6(4):304-312. - PMC - PubMed
    1. Olivares-Morales A, Hatley OJ, Turner D, Galetin A, Aarons L, Rostami-Hodjegan A. The use of ROC analysis for the qualitative prediction of human oral bioavailability from animal data. Pharm Res. 2014 Mar;31(3):720-30. - PMC - PubMed
    1. Doogue MP, Polasek TM. The ABCD of clinical pharmacokinetics. Ther Adv Drug Saf. 2013 Feb;4(1):5-7. - PMC - PubMed

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