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. 2020 Jun 4;15(6):e0233718.
doi: 10.1371/journal.pone.0233718. eCollection 2020.

Sex-specific associations between person and environment-related childhood adverse events and levels of cortisol and DHEA in adolescence

Lotte van Dammen  1   2   3 , Susanne R de Rooij  4   5 , Pia M Behnsen  5 , Anja C Huizink  5   6
Affiliations

Sex-specific associations between person and environment-related childhood adverse events and levels of cortisol and DHEA in adolescence

Lotte van Dammen et al. PLoS One. .

Abstract

Background: Person and environment-related childhood adverse events have been demonstrated to increase the risk of impaired mental health in later life differently for boys and girls. Altered hypothalamic pituitary adrenal (HPA)-axis functioning has been suggested as a key mechanism underlying this association. Cortisol and dehydroepiandrosterone (DHEA) are both output hormones of the HPA-axis. DHEA may have a protective function against long-term exposure to increased levels of cortisol, but has been little investigated in relation to childhood adversity.

Objective: We aimed to test the associations between person-, and environment-related childhood adversity and levels of cortisol, DHEA and cortisol/DHEA ratio in adolescent boys and girls.

Methods: A total of 215 Dutch adolescents participated in the study and filled out the 27-item Adverse Life Events Questionnaire for the assessment of childhood adversity, which was split up in separate scores for person-related and environment-related events. Cortisol and DHEA concentrations and cortisol/DHEA ratio were determined in proximal 3 cm long hair segments. Additionally, saliva samples were collected immediately and 30 minutes after waking up, at noon and at 8 pm. Multiple linear regression analyses were used to test associations between childhood adversity and cortisol and DHEA concentrations, for boys and girls separately, with age, BMI and pubertal development as covariates.

Results: Data were available for 74 boys and 116 girls with a mean age of 15.7 years (SD = 2.0). Higher levels of person-related childhood adversity were associated with higher hair DHEA levels in girls and with higher hair cortisol levels in boys. A trend towards a significant association was observed between higher levels of environment-related childhood adversity and higher DHEA levels in boys. Neither person- nor environment related childhood adversity was associated with cortisol/DHEA ratio. A trend was observed for environment-related childhood adversity and lower daily cortisol output in boys.

Conclusion: We found differential associations between childhood adversity and cortisol and DHEA levels in girls and boys, for respectively person-related and environment-related childhood adversity. Our findings suggest that different types of childhood adversity are not only linked to levels of cortisol, but also to DHEA concentrations, in a sex-specific manner, with possible future implications for mental health.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of participants and data availability for questionnaires, hair (part 1) and saliva (part 2).
Fig 2
Fig 2. Daily cortisol output from saliva for boys with and without environment-related adversity.
Fig 3
Fig 3. Daily cortisol output from saliva for boys with and without person-related adversity.
Fig 4
Fig 4. Daily cortisol output from saliva for girls with and without environment-related adversity.
Fig 5
Fig 5. Daily cortisol output from saliva for girls with and without person-related adversity.
See this image and copyright information in PMC

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