Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun 3;106(5):709-711.
doi: 10.1016/j.neuron.2020.05.012.

Salty Taste: From Transduction to Transmitter Release, Hold the Calcium

Emily R Liman  1
Affiliations
Free article
Comment

Salty Taste: From Transduction to Transmitter Release, Hold the Calcium

Emily R Liman. Neuron. .
Free article

Abstract

Detection of NaCl by the gustatory system is fundamental for salt intake and tissue homeostasis. Yet, signal transduction mechanisms for salty taste have remained obscure. In this issue of Neuron, Nomura et al. (2020) report that the epithelial sodium channel ENaC, which serves as the salty receptor, is co-expressed with the voltage-activated ATP release channel CALHM1/3 in a subset of taste cells and that these cells mediate amiloride-sensitive salty taste.

Keywords: CALHM1; CALHM3; ENaC; amiloride; gustatory; purinergic; salty; sodium channel; taste.

PubMed Disclaimer

Comment on

LinkOut - more resources