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. 2020 Jun 2;9(6):476.
doi: 10.3390/antiox9060476.

Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study

Bernardo U Peres  1 , A J Hirsch Allen  2 , Aditi Shah  2   3   4 , Nurit Fox  2 , Ismail Laher  5 , Fernanda Almeida  1 , Rachel Jen  2   3 , Najib Ayas  2   3   4
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Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study

Bernardo U Peres et al. Antioxidants (Basel). .

Abstract

Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m2). In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (p = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (p < 0.0001) and no previous history of cardiovascular disease (p = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA.

Keywords: biomarkers; obstructive sleep apnea (OSA); oxidative stress.

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Conflict of interest statement

All authors declare no conflict of interest.

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References

    1. Benjafield A.V., Ayas N.T., Eastwood P.R., Heinzer R., Ip M.S.M., Morrell M.J., Nunez C.M., Patel S.R., Penzel T., Pépin J.-L., et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis. Lancet Respir. Med. 2019;7:687–698. doi: 10.1016/S2213-2600(19)30198-5. - DOI - PMC - PubMed
    1. Bradley T.D., Floras J.S. Obstructive sleep apnoea and its cardiovascular consequences. Lancet. 2009;373:82–93. doi: 10.1016/S0140-6736(08)61622-0. - DOI - PubMed
    1. Young T., Finn L., Peppard P.E., Szklo-Coxe M., Austin D., Nieto F.J., Stubbs R., Hla K.M. Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort. Sleep. 2008;31:1071–1078. - PMC - PubMed
    1. Yaggi H.K., Kernan W.N., Brass L.M. Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. N. Engl. J. Med. 2005;353:2034–2041. doi: 10.1056/NEJMoa043104. - DOI - PubMed
    1. Abuyassin B., Sharma K., Ayas N.T., Laher I. Obstructive Sleep Apnea and Kidney Disease: A Potential Bidirectional Relationship? J. Clin. Sleep Med. 2015;11:915–924. doi: 10.5664/jcsm.4946. - DOI - PMC - PubMed

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