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Review
. 2020 Jun 2;9(6):1706.
doi: 10.3390/jcm9061706.

Optical Coherence Tomography Angiography in Neurodegenerative Disorders

Marco Pellegrini  1 , Aldo Vagge  2 , Lorenzo Ferro Ferro Desideri  2 , Federico Bernabei  1 , Giacinto Triolo  3 , Rodolfo Mastropasqua  4 , Chiara Del Del Noce  2 , Enrico Borrelli  5 , Riccardo Sacconi  5 , Claudio Iovino  6 , Antonio Di Di Zazzo  7 , Matteo Forlini  8 , Giuseppe Giannaccare  9
Affiliations
Review

Optical Coherence Tomography Angiography in Neurodegenerative Disorders

Marco Pellegrini et al. J Clin Med. .

Abstract

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible 'window' to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT-A in glaucoma and central nervous system conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT-A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

Keywords: Alzheimer’s disease; Parkinson’s disease; glaucoma; multiple sclerosis; neurodegenerative disorders; optical coherence tomography angiography.

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Conflict of interest statement

The authors declare no conflict of interest.

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