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Review
. 2021 Jan 2;17(1):293-303.
doi: 10.1080/21645515.2020.1767449. Epub 2020 Jun 4.

Staphylococcal Vaccine Antigens related to biofilm formation

Bahman Mirzaei  1   2 , Ryhaneh Babaei  2 , Sina Valinejad  2
Affiliations
Review

Staphylococcal Vaccine Antigens related to biofilm formation

Bahman Mirzaei et al. Hum Vaccin Immunother. .

Abstract

The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.

Keywords: staphylococcus aureus; staphylococcus epidermidis; Candidate vaccines; biofilm; device-related infection; immunotherapy; nosocomial pathogen; prophylaxis.

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References

    1. Anderson AS, Scully IL, Timofeyeva Y, Murphy E, McNeil LK, Mininni T, Nuñez L, Carriere M, Singer C, Dilts DA, et al. Staphylococcus aureus manganese transport protein C is a highly conserved cell surface protein that elicits protective immunity against S. aureus and Staphylococcus epidermidis. J Infect Dis. 2012;205(11):1688–96. doi:10.1093/infdis/jis272. - DOI - PMC - PubMed
    1. van Belkum A. Staphylococcal colonization and infection: homeostasis versus disbalance of human (innate) immunity and bacterial virulence. Curr Opin Infect Dis. 2006;19(4):339–44. doi:10.1097/01.qco.0000235159.40184.61. - DOI - PubMed
    1. Jones SM, Morgan M, Humphrey TJ, Lappin-Scott H.. Effect of vancomycin and rifampicin on meticillin-resistant Staphylococcus aureus biofilms. Lancet (London, England). 2001;357(9249):40–41. doi:10.1016/s0140-6736(00)03572-8. - DOI - PubMed
    1. Kuklin NA, Clark DJ, Secore S, Cook J, Cope LD, McNeely T, Noble L, Brown MJ, Zorman JK, Wang XM, et al. A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis model. Infect Immun. 2006;74(4):2215–23. doi:10.1128/iai.74.4.2215-2223.2006. - DOI - PMC - PubMed
    1. Hogea C, Van Effelterre T, Cassidy A. A model-based analysis: what potential could there be for a S. aureus vaccine in a hospital setting on top of other preventative measures? BMC Infect Dis. 2014;14(1):291. doi:10.1186/1471-2334-14-291. - DOI - PMC - PubMed

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