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Review
. 2021 Jan 2;17(1):293-303.
doi: 10.1080/21645515.2020.1767449. Epub 2020 Jun 4.

Staphylococcal Vaccine Antigens related to biofilm formation

Bahman Mirzaei  1   2 , Ryhaneh Babaei  2 , Sina Valinejad  2
Affiliations
Review

Staphylococcal Vaccine Antigens related to biofilm formation

Bahman Mirzaei et al. Hum Vaccin Immunother. .

Abstract

The number and frequency of multidrug-resistant (MDR) strains as a frequent cause of nosocomial infections have increased, especially for Methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, in part due to device-related infections. The transition to antibiotic-resistance in related bacterial genes and the capability for immune escape have increased the sustainability of biofilms produced by these bacteria. The formation and changes in biofilms have been suggested as a target to prevent or treat staphylococcal infections. Thus, this study reviews the development of candidate staphylococcal vaccines by database searching, and evaluates the immunogenicity and efficacy profiles of bacterial components involved in biofilms. The literature suggests that using common staphylococcal vaccine antigens and multivalent vaccines should further enhance vaccine efficacy.

Keywords: staphylococcus aureus; staphylococcus epidermidis; Candidate vaccines; biofilm; device-related infection; immunotherapy; nosocomial pathogen; prophylaxis.

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