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Editorial
. 2020 Jun 9;75(22):2781-2784.
doi: 10.1016/j.jacc.2020.04.054.

An Outbreak of Polygenic Scores for Coronary Artery Disease

Jerome I Rotter  1 , Henry J Lin  2
Affiliations
Editorial

An Outbreak of Polygenic Scores for Coronary Artery Disease

Jerome I Rotter et al. J Am Coll Cardiol. .
No abstract available

Keywords: coronary artery disease; genetic risk; primary prevention; statin.

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Figures

None
Graphical abstract
Figure 1
Figure 1
Illustration of False Positive and CAD Detection Rates for CAD Polygenic Scores Shown are distributions of polygenic scores for people with coronary artery disease (CAD) (solid line) and controls (dashed line). The vertical line indicates a possible polygenic score cutoff for predictive testing (at scores giving a false positive rate of 5%, in this drawing). The false positive rate is the proportion of control individuals with positive scores = dark gray/[dark gray + light gray + blue]. The detection rate is the proportion of patients with CAD with positive scores = [orange + dark gray]/[orange + dark gray + yellow + light gray]. The CAD detection rate is low at the cutoff used. The false positive rate will be higher for scores with higher detection rates. The figure was adapted from Supplemental Figure 1 (all ancestries; normalized score; Partners Healthcare Biobank) in Aragam et al. (1).
See this image and copyright information in PMC

Comment on

  • Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.
    Aragam KG, Dobbyn A, Judy R, Chaffin M, Chaudhary K, Hindy G, Cagan A, Finneran P, Weng LC, Loos RJF, Nadkarni G, Cho JH, Kember RL, Baras A, Reid J, Overton J, Philippakis A, Ellinor PT, Weiss ST, Rader DJ, Lubitz SA, Smoller JW, Karlson EW, Khera AV, Kathiresan S, Do R, Damrauer SM, Natarajan P. Aragam KG, et al. J Am Coll Cardiol. 2020 Jun 9;75(22):2769-2780. doi: 10.1016/j.jacc.2020.04.027. J Am Coll Cardiol. 2020. PMID: 32498804 Free PMC article.

References

    1. Aragam K.G., Dobbyn A., Judy R. Limitations of contemporary guidelines for managing patients at high genetic risk of coronary artery disease. J Am Coll Cardiol. 2020;75:2769–2780. - PMC - PubMed
    1. Fisher R.A. The correlation between relatives on the supposition of Mendelian inheritance. Trans Roy Soc Edin. 1918;52:399–433.
    1. Wigan L.G. Balance and potence in natural populations. J Genet. 1944;46:150–160.
    1. Mather K. Polygenic inheritance and natural selection. Biol Rev. 1943;18:32–64.
    1. Mather K. Methuen and Company Ltd; London, UK: 1949. Biometrical Genetics: The Study of Continuous Variation.