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Case Reports
. 2020 Jul;20(5):1011-1012.
doi: 10.1016/j.pan.2020.05.016. Epub 2020 May 28.

SARS-CoV2 RNA detection in a pancreatic pseudocyst sample

T Schepis  1 , A Larghi  2 , A Papa  2 , L Miele  2 , F Panzuto  3 , L De Biase  4 , B Annibale  3 , P Cattani  5 , G L Rapaccini  2
Affiliations
Case Reports

SARS-CoV2 RNA detection in a pancreatic pseudocyst sample

T Schepis et al. Pancreatology. 2020 Jul.

Abstract

The involvement of gastrointestinal system in SARS-CoV2 related disease, COVID-19, is increasingly recognized. COVID-19 associated pancreatic injury has been suggested, but its correlation with pancreatic disease is still unclear. In this case report, we describe the detection of SARS-CoV2 RNA in a pancreatic pseudocyst fluid sample collected from a patient with SARS-CoV2 associated pneumonia and a pancreatic pseudocyst developed as a complication of an acute edematous pancreatitis. The detection of SARS-CoV2 within the pancreatic collection arise the question of whether this virus has a tropism for pancreatic tissue and whether it plays a role in pancreatic diseases occurrence.

Keywords: Covid-19; Endoscopic drainage; Pancreatic pseudocyst; SARS-CoV2.

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Conflict of interest statement

Declaration of competing interest A. Larghi: training and fees for Boston Scientific, Medtronic and Pentax. All other authors disclosed no conflict of interest.

Figures

Fig. 1
Fig. 1
Abdominal CT scans showing (a) the large pancreatic pseudocyst measuring 16 cm × 8 cm x 12 cm (∗) and (b) the Lumen Apposing Metal Stent (white narrow) placed transmurally between stomach (∗) and pancreatic pseudocyst (#). (c) Chest CT scan showing bilateral and multiple mottling and ground glass opacities compatible with SARS-CoV2 associated pneumonia.
See this image and copyright information in PMC

References

    1. Hadi A et al., Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: Case report on three familymembers, Pancreatology, https://doi.org/10.1016/j.pan.2020.04.021. - PMC - PubMed
    1. Aloysius M.M., Thatti A., Gupta A., Sharma N., Bansal P., Goyal H. COVID-19presenting as acute pancreatitis. Pancreatology. 2020 doi: 10.1016/j.pan.2020.05. - DOI - PMC - PubMed
    1. Wang F., Wang H., Fan J., et al. Pancreatic injury patterns in patients with COVID-19 pneumonia. Gastroenterology. 2020 Apr 1;20:30409–30411. pii: S0016-5085. - PMC - PubMed
    1. Zhang H, Kang Z, Gong H, et al. Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. Gut Published Online First: 02 April 2020. doi: 10.1136/gutjnl-2020-320953
    1. Chen Y., Guo Y., et al. Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun. 2020 Feb 17;20 pii: S0006-291X. 30339-9. - PMC - PubMed