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Comment
. 2020 Jun 5;368(6495):1053-1054.
doi: 10.1126/science.abc2732.

Testicular-borne factors affect sperm fertility

Tessa Lord  1 , Jon M Oatley  2
Affiliations
Comment

Testicular-borne factors affect sperm fertility

Tessa Lord et al. Science. .
No abstract available

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Figures

figure
figure. Lumicrine regulation of epididymal development and function
Lumicrine factors, such as neural epidermal growth factor–like like 2 (NELL2), are produced by germ cells in the testis during maturation of the epithelial cells that line the initial segment (IS) of the epididymis through activation of c-ros oncogene 1 (ROS1). Mature IS cells produce ovochymase 2 (OVCH2), which cleaves a disintegrin and metallopeptidase domain 3 (ADAM3) on immature sperm to attain fertilization competency.
See this image and copyright information in PMC

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