Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 May 15:7:61.
doi: 10.3389/fcvm.2020.00061. eCollection 2020.

Mitral and Tricuspid Transcatheter Interventions Current Indications and Future Directions

Affiliations
Review

Mitral and Tricuspid Transcatheter Interventions Current Indications and Future Directions

Mirjam Gauri Winkel et al. Front Cardiovasc Med. .

Abstract

Valvular heart disease is responsible for a high rate of morbidity and mortality, especially in the elderly population. With the emergence of new transcatheter treatment options, the therapeutic spectrum for patients with valvular heart disease has considerably expanded during the past years. Interventional treatment of the mitral and tricuspid valve requires an individualized and versatile approach owing to the different etiologies of valvular dysfunction and the complex anatomy of the atrioventricular valves. This article aims to review recent developments, summarize the evidence, indications and limitations of the available systems, and provide a glimpse into the future of transcatheter interventions for the treatment of mitral and tricuspid valve disease.

Keywords: annuloplasty; cardioband; edge-to-edge repair; mitraclip; mitral interventions; pascal; tricuspid interventions; valvular heart disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Case of leaflet approximation with PASCAL device in secondary MR. (A) Baseline color-Doppler echocardiographic assessment of MR. (B) Leaflet clasping. (C) Schematic depiction of the PASCAL system (courtesy of Edwards Lifesciences). (D) Assessment of the final result with color Doppler echocardiography.
Figure 2
Figure 2
Decision algorithm for transcatheter tricuspid valve interventions. TR, tricuspid regurgitation; OMT, optimal medical therapy; PHT, pulmonary hypertension; RV, right ventricle.
Figure 3
Figure 3
Case of combined mitral and tricuspid edge-to-edge repair in a 79-year old sympatomatic (NYHA III) male patient with prohibitive surgical risk (Euroscore II 21%). Baseline transesophageal assessment showed severe MR (A). After transseptal puncture, the mitral valve was treated first with the placement of one MitraClip XTR. with MR reduction to grade 1+ (B). Severe TR at baseline (C) Two MitraClip XTR were placed in the anteroseptal commissure with reduction of TR to mild (D). Final fluoroscopic result ((E), *MitraClip mitral, + MitraClips tricuspid).

References

    1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. (2006) 368:1005–11. 10.1016/S0140-6736(06)69208-8 - DOI - PubMed
    1. Topilsky Y, Maltais S, Medina Inojosa J, Oguz D, Michelena H, Maalouf J, et al. . Burden of tricuspid regurgitation in patients diagnosed in the community setting. JACC Cardiovasc Imaging. (2018) 12:433–42. 10.1016/j.jcmg.2018.06.014 - DOI - PubMed
    1. Moore M, Chen J, Mallow PJ, Rizzo JA. The direct health-care burden of valvular heart disease: evidence from US national survey data. ClinicoEcon Outcomes Res. (2016) 8:613–27. 10.2147/CEOR.S112691 - DOI - PMC - PubMed
    1. Andalib A, Mamane S, Schiller I, Zakem A, Mylotte D, Martucci G, et al. . A systematic review and meta-analysis of surgical outcomes following mitral valve surgery in octogenarians: implications for transcatheter mitral valve interventions. EuroIntervention. (2014) 9:1225–34. 10.4244/EIJV9I10A205 - DOI - PubMed
    1. Mirabel M, Iung B, Baron G, Messika-Zeitoun D, Detaint D, Vanoverschelde JL, et al. . What are the characteristics of patients with severe, symptomatic, mitral regurgitation who are denied surgery? Eur Heart J. (2007) 28:1358–65. 10.1093/eurheartj/ehm001 - DOI - PubMed