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Review
. 2020 Jul 16;15(14):2092-2109.
doi: 10.1002/asia.202000506. Epub 2020 Jun 30.

Transition Metal-Catalysed Direct C-H Bond Functionalizations of 2-Pyridone Beyond C3-Selectivity

Aniruddha Biswas  1 , Saurabh Maity  1   2 , Subarna Pan  1 , Rajarshi Samanta  1
Affiliations
Review

Transition Metal-Catalysed Direct C-H Bond Functionalizations of 2-Pyridone Beyond C3-Selectivity

Aniruddha Biswas et al. Chem Asian J. .

Abstract

2-Pyridone is a ubiquitous motif in natural products, drug molecules, ligands in catalysis and organic materials. There is a necessity of direct step-economic methods for the construction of 2-pyridone based molecules. Strategically, the primary developments have led to the C3-functionalizations due to the inherent reactivity of this center. Despite this, many elegant transition metal-catalysed methods have been established to introduce versatile functional groups at the C4, C5 and C6-position via direct C-H bond functionalizations. This minireview focuses on the categorized introduction of different functional groups at the 2-pyridone scaffolds beyond C3-selectivity and discusses substrate scope, limitations and plausible mechanistic details.

Keywords: 2-Pyridone; Beyond C-3; C−H Functionalizations; Regioselectivity; Transition-Metal-Catalysis.

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