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Randomized Controlled Trial
. 2020 Aug;9(15):5345-5352.
doi: 10.1002/cam4.3194. Epub 2020 Jun 4.

Patient-controlled subcutaneous analgesia using sufentainil or morphine in home care treatment in patients with stage III-IV cancer: A multi-center randomized controlled clinical trial

Cheng-Fu Wan  1 , Qing-Zhu Meng  2 , Yan-Wei Wang  3 , Liang Qi  4 , Chang-Liang Ai  5 , Xin Sui  6 , Tao Song  1
Affiliations
Randomized Controlled Trial

Patient-controlled subcutaneous analgesia using sufentainil or morphine in home care treatment in patients with stage III-IV cancer: A multi-center randomized controlled clinical trial

Cheng-Fu Wan et al. Cancer Med. 2020 Aug.

Abstract

Purpose: Patient-controlled subcutaneous analgesia (PCSA) with sufentanil is an alternative analgesia strategy in patients with stage III-IV cancer; however, its efficacy and safety have not been fully investigated.

Methods: From May 10, 2017 to November 10, 2017, 120 patients with stage III-IV cancer suffering from moderate to severe pain were prospectively enrolled from six hospitals and randomized to receive PCSA with morphine (control group) or sufentanil (intervention group). Before the PCSA and on days 1, 3, 7, 14, 28, and 56 after treatment, the numeric rating scale (NRS) and 36-item Short Form health survey (SF-36) were completed for each patient and the side effects were also recorded.

Results: No significant differences (P > .05) were observed in the preoperative NRS score and the SF-36 parameters between the two groups. Patients in the intervention group achieved better pain relief, as indicated by lower NRS scores at days 14 (P = .040), 28 (P < .001), and 56 (P < .001) after PCSA device implantation (vs control group). Furthermore, the patients in the intervention group also achieved a better life quality, as indicated by the physical role, general health, social function body pain, and mental health scores. Finally, the patients receiving sufentanil showed lower levels of nausea and somnolence than those in the control group.

Conclusion: PCSA with sufentanil achieves better pain control and life quality as well as fewer adverse reactions in stage III-IV cancer patients with pain and may be a promising pain management in these patients.

Trial registration: This study was registered at chictr.org.cn with the trial number: ChiCTR-IPR-17011280.

Keywords: 36-item Short Form health survey; advanced cancer; numeric rating scale; patient-controlled subcutaneous analgesia; sufentanil.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

FIGURE 1
FIGURE 1
CONSORT flowchart
FIGURE 2
FIGURE 2
Subcutaneous catheter fixation around the navel
FIGURE 3
FIGURE 3
Alterations of the mean numeric rating scale (NRS) scores after patient‐controlled subcutaneous analgesia (PCSA) with morphine (Control) or sufentanil (Intervention). Data were expressed as mean ± SD
FIGURE 4
FIGURE 4
Changes in the SF‐36 parameters after PCSA with morphine (Control) or sufentanil (Intervention). Data were expressed as mean ± SD
FIGURE 5
FIGURE 5
The incidences of adverse events between the two groups. Data were expressed as mean ± SD
See this image and copyright information in PMC

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