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Review
. 2021 Apr;1490(1):3-12.
doi: 10.1111/nyas.14382. Epub 2020 Jun 5.

Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov  1   2   3   4 , Yubao Gong  1   5 , Daniel J Leong  1   2   4 , Konrad I Gruson  1 , Deyou Zheng  6   7   8 , David T Fung  4 , Li Sun  4 , Hui B Sun  1   2   4
Affiliations
Review

Advances in the development of gene therapy, noncoding RNA, and exosome-based treatments for tendinopathy

Angela Wang Ilaltdinov et al. Ann N Y Acad Sci. 2021 Apr.

Abstract

Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments for tendinopathy. The review also highlights recent advances in gene therapy, the potential of noncoding RNAs, such as microRNAs, and exosomes, which are nanometer-sized extracellular vesicles secreted from cells, for the treatment of tendinopathy.

Keywords: exosomes; extracellular vesicles; gene therapy; lncRNA; miRNA.

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References

    1. Sharma, P. & N. Maffulli. 2006. Understanding and managing Achilles tendinopathy. Br. J. Hosp. Med. 67: 64-67.
    1. Järvinen, T.A.H., P. Kannus, N. Maffulli, et al. 2005. Achilles tendon disorders: etiology and epidemiology. Foot Ankle Clin. 10: 255-266.
    1. Raikin, S.M., D.N. Garras & P.V. Krapchev. 2013. Achilles tendon injuries in a United States population. Foot Ankle Int. 34: 475-480.
    1. Andarawis-Puri, N., E.L. Flatow & L.J. Soslowsky. 2015. Tendon basic science: development, repair, regeneration, and healing. J. Orthop. Res. 33: 780-784.
    1. Lewis, J., K. McCreesh, J.-S. Roy, et al. 2015. Rotator cuff tendinopathy: navigating the diagnosis-management conundrum. J. Orthopaed. Sports Phys. Ther. 45: 923-937.