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Observational Study
. 2020 Aug;39(8):737-739.
doi: 10.1097/INF.0000000000002733.

Progressive Decline of the Glomerular Filtration Rate in HIV-infected Children Treated With Tenofovir Disoproxil Fumarate-based Regimens in West and Central Africa

Aminata Diack  1 , Caroline Yonaba  2 , Aba Coulibaly  3 , Sylvie Ouedraogo  4 , Ida Penda  5 , Hélène Bukuru  6 , Madeleine Folquet  7 , François Tanoh Eboua  8 , Mariam Sylla  3 , Stéphane Blanche  9 , Mathurin Tejiokem  10 ; Enfants VIH Afrique network
Affiliations
Observational Study

Progressive Decline of the Glomerular Filtration Rate in HIV-infected Children Treated With Tenofovir Disoproxil Fumarate-based Regimens in West and Central Africa

Aminata Diack et al. Pediatr Infect Dis J. 2020 Aug.

Abstract

A cross-sectional study of 358 HIV-1-infected children and adolescents living in Sub-Saharan Africa treated with tenofovir disoproxil fumarate-based regimens for a median of 1.5 interquartile range [0.6-3.1 years] showed a loss of glomerular filtration rate estimated to be 0.41 mL/min/1.73 m per month of treatment. In contrast, there was no decrease depending on the duration of the previous antiretroviral treatment.

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References

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