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Comment
. 2020 Jun 4;26(6):797-799.
doi: 10.1016/j.stem.2020.05.005.

Colon Cancer Heterogeneity: Welcome to the RiboZone

Robert Piskol  1 , Felipe de Sousa E Melo  2
Affiliations
Comment

Colon Cancer Heterogeneity: Welcome to the RiboZone

Robert Piskol et al. Cell Stem Cell. .

Abstract

In this issue of Cell Stem Cell, Morral et al. (2020) shed new light on the hierarchical organization of cells within colorectal cancer. They show that tumor cells at the apex of this hierarchy reside in particular tumor zones and possess high protein synthesis activity. Interference with their biosynthetic activity results in an irreversible growth arrest of CRC.

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Conflict of interest statement

Declaration of Interests R.P. and F.d.S.e.M. are employees of Genentech and own shares of Roche.

Comment on

  • Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer.
    Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Álvarez-Varela A, Cortina C, Stork D, Slebe F, Turon G, Whissell G, Sevillano M, Merlos-Suárez A, Casanova-Martí À, Moutinho C, Lowe SW, Dow LE, Villanueva A, Sancho E, Heyn H, Batlle E. Morral C, et al. Cell Stem Cell. 2020 Jun 4;26(6):845-861.e12. doi: 10.1016/j.stem.2020.04.012. Epub 2020 May 11. Cell Stem Cell. 2020. PMID: 32396863 Free PMC article.