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Comment
. 2020 Jun 4;26(6):799-801.
doi: 10.1016/j.stem.2020.05.009.

There's No I in Team: Cellular Crosstalk Enhances In Vitro Cardiac Maturation

Richard J Mills  1 , James E Hudson  2
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There's No I in Team: Cellular Crosstalk Enhances In Vitro Cardiac Maturation

Richard J Mills et al. Cell Stem Cell. .
Free article

Abstract

Organoids and microtissues offer the unique opportunity to dissect cell-cell interactions in an organ-specific context without confounding effects of organ failure or organism viability. In a study in this issue of Cell Stem Cell, Giacomelli et al. (2020) add human cardiac fibroblasts into cardiac microtissues and reveal striking fibroblast-endothelial-cardiomyocyte crosstalk that promotes advanced cardiomyocyte maturation.

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Conflict of interest statement

Declaration of Interests R.J.M. and J.E.H. are listed as co-inventors on pending patents held by The University of Queensland and QIMR Berghofer Medical Research Institute that relate to cardiac organoid maturation and putative cardiac regeneration therapeutics. J.E.H. is a co-inventor on licensed patents held by the University of Goettingen. R.J.M and J.E.H. are co-founders, scientific advisors, and stockholders in Dynomics.

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