Skinny Fat Cells Stimulate Wound Healing

David Merrick¹, Patrick Seale²

Affiliations

¹ Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: david.merrick@pennmedicine.upenn.edu.
² Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sealep@pennmedicine.upenn.edu.

PMID: 32502400
DOI: 10.1016/j.stem.2020.04.021

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Skinny Fat Cells Stimulate Wound Healing

David Merrick et al. Cell Stem Cell. 2020.

Free article

. 2020 Jun 4;26(6):801-803.

doi: 10.1016/j.stem.2020.04.021.

Authors

David Merrick¹, Patrick Seale²

Affiliations

¹ Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: david.merrick@pennmedicine.upenn.edu.
² Institute for Diabetes, Obesity & Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: sealep@pennmedicine.upenn.edu.

PMID: 32502400
DOI: 10.1016/j.stem.2020.04.021

Abstract

In this issue of Cell Stem Cell, Shook et al. (2020) reveal that dermal adipocytes regulate skin wound repair via release of fatty acids that promote macrophage recruitment and accelerated revascularization. Furthermore, mature dermal adipocytes dedifferentiate into migratory extracellularmatrix-producing myofibroblasts.

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Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Shook BA, et al. Cell Stem Cell. 2020 Jun 4;26(6):880-895.e6. doi: 10.1016/j.stem.2020.03.013. Epub 2020 Apr 16. Cell Stem Cell. 2020. PMID: 32302523 Free PMC article.

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Skinny Fat Cells Stimulate Wound Healing

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Skinny Fat Cells Stimulate Wound Healing

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