End Products of Telomere Research

Roger R Reddel¹, Karen L MacKenzie², Tracy M Bryan³

Affiliations

¹ Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia. Electronic address: rreddel@cmri.org.au.
² Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW 2052, Australia.
³ Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia.

PMID: 32502401
DOI: 10.1016/j.stem.2020.05.006

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End Products of Telomere Research

Roger R Reddel et al. Cell Stem Cell. 2020.

Free article

. 2020 Jun 4;26(6):804-805.

doi: 10.1016/j.stem.2020.05.006.

Authors

Roger R Reddel¹, Karen L MacKenzie², Tracy M Bryan³

Affiliations

¹ Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia. Electronic address: rreddel@cmri.org.au.
² Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW 2052, Australia.
³ Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW 2145, Australia.

PMID: 32502401
DOI: 10.1016/j.stem.2020.05.006

Abstract

Most rare inherited telomere biology disorders and some common aging-related diseases are associated with shortened telomeres. In this issue of Cell Stem Cell, insights into one of the rarest genetic causes of these disorders led to the discovery (Nagpal et al., 2020) of small molecules that lengthen telomeres.

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Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells.
Nagpal N, Wang J, Zeng J, Lo E, Moon DH, Luk K, Braun RO, Burroughs LM, Keel SB, Reilly C, Lindsley RC, Wolfe SA, Tai AK, Cahan P, Bauer DE, Fong YW, Agarwal S. Nagpal N, et al. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8. doi: 10.1016/j.stem.2020.03.016. Epub 2020 Apr 21. Cell Stem Cell. 2020. PMID: 32320679 Free PMC article.

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End Products of Telomere Research

Affiliations

End Products of Telomere Research

Authors

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