A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation

Katrine T Schjoldager¹, Henrik Clausen², Ramon Hurtado-Guerrero³

Affiliations

¹ Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. Electronic address: schjoldager@sund.ku.dk.
² Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. Electronic address: hclau@sund.ku.dk.
³ Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark; BIFI, University of Zaragoza, Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain. Electronic address: rhurtado@bifi.es.

PMID: 32502418
DOI: 10.1016/j.molcel.2020.05.019

Free article

Comment

A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation

Katrine T Schjoldager et al. Mol Cell. 2020.

Free article

. 2020 Jun 4;78(5):803-805.

doi: 10.1016/j.molcel.2020.05.019.

Authors

Katrine T Schjoldager¹, Henrik Clausen², Ramon Hurtado-Guerrero³

Affiliations

¹ Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. Electronic address: schjoldager@sund.ku.dk.
² Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark. Electronic address: hclau@sund.ku.dk.
³ Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark; BIFI, University of Zaragoza, Institute for Biocomputation and Physics of Complex Systems (BIFI), Mariano Esquillor s/n, Campus Rio Ebro, Edificio I+D, Zaragoza, Spain. Electronic address: rhurtado@bifi.es.

PMID: 32502418
DOI: 10.1016/j.molcel.2020.05.019

Abstract

In this issue of Molecular Cell, Schumann et al. (2020) present a novel strategy to dissect the regulation of protein O-glycosylation by a large family of isoenzymes in cells. They employ a bump-and-hole engineering approach to capture the specific contribution of individual isoenzymes to O-glycosylation of proteins.

PubMed Disclaimer

Comment on

Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells.
Schumann B, Malaker SA, Wisnovsky SP, Debets MF, Agbay AJ, Fernandez D, Wagner LJS, Lin L, Li Z, Choi J, Fox DM, Peh J, Gray MA, Pedram K, Kohler JJ, Mrksich M, Bertozzi CR. Schumann B, et al. Mol Cell. 2020 Jun 4;78(5):824-834.e15. doi: 10.1016/j.molcel.2020.03.030. Epub 2020 Apr 22. Mol Cell. 2020. PMID: 32325029 Free PMC article.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation

Affiliations

A Bump-and-Hole Approach to Dissect Regulation of Protein O-Glycosylation

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources