SARS-CoV-2: Is the liver merely a bystander to severe disease?

Mansoor N Bangash¹, Jaimin M Patel², Dhruv Parekh², Nicholas Murphy², Rachel M Brown³, Ahmed M Elsharkawy⁴, Gautam Mehta⁵, Matthew J Armstrong⁴, Desley Neil³

Affiliations

¹ Liver Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK; Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK. Electronic address: mansoor.bangash@uhb.nhs.uk.
² Liver Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK; Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.
³ Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Department of Cellular Pathology, QEHB, Mindelsohn Way, Birmingham, UK; Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.
⁴ Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK.
⁵ Institute for Liver and Digestive Health, Royal Free Campus, UCL, London, UK; Institute of Hepatology, Foundation for Liver Research, London, UK.

PMID: 32502510
PMCID: PMC7265856
DOI: 10.1016/j.jhep.2020.05.035

Comment

SARS-CoV-2: Is the liver merely a bystander to severe disease?

Mansoor N Bangash et al. J Hepatol. 2020 Oct.

. 2020 Oct;73(4):995-996.

doi: 10.1016/j.jhep.2020.05.035. Epub 2020 Jun 2.

Authors

Mansoor N Bangash¹, Jaimin M Patel², Dhruv Parekh², Nicholas Murphy², Rachel M Brown³, Ahmed M Elsharkawy⁴, Gautam Mehta⁵, Matthew J Armstrong⁴, Desley Neil³

Affiliations

¹ Liver Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK; Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK. Electronic address: mansoor.bangash@uhb.nhs.uk.
² Liver Intensive Care Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK; Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.
³ Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Department of Cellular Pathology, QEHB, Mindelsohn Way, Birmingham, UK; Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK.
⁴ Birmingham Liver Failure Research Group, Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Institute of Inflammation and Ageing, NIHR Biomedical Research Centre, University of Birmingham, Birmingham, UK; Liver Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Birmingham, UK.
⁵ Institute for Liver and Digestive Health, Royal Free Campus, UCL, London, UK; Institute of Hepatology, Foundation for Liver Research, London, UK.

PMID: 32502510
PMCID: PMC7265856
DOI: 10.1016/j.jhep.2020.05.035

No abstract available

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Conflict of interest statement

Conflict of interest Dr. Armstrong reports personal fees from Novo Nordisk, outside the submitted work. All other authors have no conflicts of interest to declare. Please refer to the accompanying ICMJE disclosure forms for further details.

Comment in

Reply to: Correspondence relating to "SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19".
Wang Y, Lu F, Zhao J. Wang Y, et al. J Hepatol. 2020 Oct;73(4):996-998. doi: 10.1016/j.jhep.2020.06.028. Epub 2020 Jun 23. J Hepatol. 2020. PMID: 32589896 Free PMC article. No abstract available.

Comment on

SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19.
Wang Y, Liu S, Liu H, Li W, Lin F, Jiang L, Li X, Xu P, Zhang L, Zhao L, Cao Y, Kang J, Yang J, Li L, Liu X, Li Y, Nie R, Mu J, Lu F, Zhao S, Lu J, Zhao J. Wang Y, et al. J Hepatol. 2020 Oct;73(4):807-816. doi: 10.1016/j.jhep.2020.05.002. Epub 2020 May 11. J Hepatol. 2020. PMID: 32437830 Free PMC article.

References

1. Wang Y., Liu S., Liu H., Li W., Lin F., Jiang L. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol. 2020;72(4):807–816. - PMC - PubMed
1. Bangash M.N., Patel J., Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol. 2020;5(6):529–530. - PMC - PubMed
1. Li W., Deng M., Loughran P.A., Yang M., Lin M., Yang C. LPS induces active HMGB1 release from hepatocytes into exosomes through the coordinated activities of TLR4 and caspase-11/GSDMD signaling. Front Immunol. 2020;11:229. - PMC - PubMed
1. Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology. 1995;21(5):1465–1468. - PubMed
1. Miller S.E., Brealey J.K. Visualization of putative coronavirus in kidney. Kidney Int. 2020;98(1):231–232. - PMC - PubMed

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SARS-CoV-2: Is the liver merely a bystander to severe disease?

Affiliations

SARS-CoV-2: Is the liver merely a bystander to severe disease?

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Conflict of interest statement

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