Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence

Ricky D Turgeon¹, Shelley Zieroth², David Bewick³, Chi-Ming Chow⁴, Brian Clarke⁵, Simone Cowan⁶, Christopher B Fordyce⁶, Anne Fournier⁷, Kenneth Gin⁶, Anil Gupta⁸, Sean Hardiman⁹, Simon Jackson¹⁰, Benny Lau⁶, Howard Leong-Poi⁴, Samer Mansour¹¹, Ariane Marelli¹², Ata Rehman Quraishi¹⁰, Idan Roifman¹³, Marc Ruel¹⁴, John Sapp¹⁰, Gurmeet Singh¹⁵, Gary Small¹⁴, Sean Virani⁶, David A Wood⁶, Andrew Krahn⁶

Affiliations

¹ Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: ricky.turgeon@gmail.com.
² University of Manitoba, Winnipeg, Manitoba, Canada.
³ New Brunswick Heart Centre, Saint John, New Brunswick, Canada.
⁴ Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
⁵ Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.
⁶ Centre for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
⁷ Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
⁸ Trillium Health Partners, University of Toronto, Mississauga, Ontario, Canada.
⁹ Cardiac Services British Columbia, Provincial Health Services Authority, Vancouver, British Columbia, Canada.
¹⁰ Queen Elizabeth II Health Sciences Center, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada.
¹¹ Department of Medicine, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.
¹² McGill University Health Center, Department of Medicine, McGill University, Montréal, Québec, Canada.
¹³ Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
¹⁴ University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
¹⁵ Mazankowski Alberta Hearth Institute, Division of Cardiac Surgery, Departments of Critical Care Medicine and Surgery, University of Alberta, Edmonton, Alberta, Canada.

PMID: 32502522
PMCID: PMC7265831
DOI: 10.1016/j.cjca.2020.05.033

Editorial

Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence

Ricky D Turgeon et al. Can J Cardiol. 2020 Aug.

. 2020 Aug;36(8):1180-1182.

doi: 10.1016/j.cjca.2020.05.033. Epub 2020 Jun 2.

Authors

Affiliations

¹ Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: ricky.turgeon@gmail.com.
² University of Manitoba, Winnipeg, Manitoba, Canada.
³ New Brunswick Heart Centre, Saint John, New Brunswick, Canada.
⁴ Division of Cardiology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
⁵ Libin Cardiovascular Institute, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta, Canada.
⁶ Centre for Cardiovascular Innovation, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
⁷ Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal, Montréal, Québec, Canada.
⁸ Trillium Health Partners, University of Toronto, Mississauga, Ontario, Canada.
⁹ Cardiac Services British Columbia, Provincial Health Services Authority, Vancouver, British Columbia, Canada.
¹⁰ Queen Elizabeth II Health Sciences Center, Division of Cardiology, Dalhousie University, Halifax, Nova Scotia, Canada.
¹¹ Department of Medicine, Centre Hospitalier de l'Université de Montréal, Université de Montréal, Montréal, Québec, Canada.
¹² McGill University Health Center, Department of Medicine, McGill University, Montréal, Québec, Canada.
¹³ Schulich Heart Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
¹⁴ University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
¹⁵ Mazankowski Alberta Hearth Institute, Division of Cardiac Surgery, Departments of Critical Care Medicine and Surgery, University of Alberta, Edmonton, Alberta, Canada.

PMID: 32502522
PMCID: PMC7265831
DOI: 10.1016/j.cjca.2020.05.033

No abstract available

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References

1. CCS COVID-19 Rapid Response Team COVID-19 and use of ACEi/ARB/ARNi medications for heart failure or hypertension. March 15, 2020. http://www.ccs.ca/images/Images_2020/CCS_CHFS_statement_regarding_COVID_... Available at:
1. Sparks M., Hiremath S. ACE2 and Hypertension. NephJC. http://www.nephjc.com/news/covidace2 Available at:
1. Mackey K, King VJ, Gurley S, et al. Risks and impact of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers on SARS-CoV-2 infection in adults: a living systematic review [e-pub before print]. Ann Intern Med 10.7326/M20-1515. - DOI - PMC - PubMed
1. de Abajo F.J., Rodríguez-Martín S., Lerma V. Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study. Lancet. 2020;395:1705–1714. - PMC - PubMed
1. Mehta N, Kalra A, Nowacki AS, et al. Association of use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with testing positive for coronavirus disease 2019 (COVID-19) [e-pub before print]. JAMA Cardiol 10.1001/jamacardio.2020.1855. - DOI - PMC - PubMed

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Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence

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Use of Renin-Angiotensin System Blockers During the COVID-19 Pandemic: Early Guidance and Evolving Evidence

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