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. 2020 Sep:286:198043.
doi: 10.1016/j.virusres.2020.198043. Epub 2020 Jun 2.

Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

Jinzhong Li  1 , Xiaobing Gong  1 , Zhigang Wang  2 , Renzhou Chen  3 , Taoyuan Li  1 , Dongyu Zeng  1 , Minran Li  4
Affiliations

Clinical features of familial clustering in patients infected with 2019 novel coronavirus in Wuhan, China

Jinzhong Li et al. Virus Res. 2020 Sep.

Abstract

An epidemic caused by SARS-Coronavirus-2 (SARS-CoV-2) infection has appeared in Wuhan City in December 2019. The disease has shown a "clustering epidemic" pattern, and family-clustered onset has been the main characteristic. We collected data about 130 cases from 35 cluster-onset families (COFs) and 41 cases from 16 solitary-onset families (SOFs). The incidence of 2019 coronavirus disease (COVID-19) in COFs was significantly higher than that of SOFs. Our study also showed that patients with exposure to high-risk factors (respiratory droplets and close contact), advanced age, and comorbidities were more likely to develop COVID-19 in the COFs. In addition, advanced age and elevated neutrophil/lymphocyte ratio (NLR) were risk factors for death in patients with SARS-CoV-2 infection in the COFs.

Keywords: 2019 Coronavirus disease; Cluster-onset families; SARS-Coronavirus-2; Solitary-onset families.

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Conflict of interest statement

The authors have no competing of interest nor any financial interest in any product mentioned in this paper.

Figures

Fig. 1
Fig. 1
Self-determined cause of infection in new-onset patients with family clustering.
Fig. 2
Fig. 2
Routes of transmission in COFs and SOFs.
See this image and copyright information in PMC

References

    1. Chan J.F., Yuan S., Kok K.H. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395:514–523. - PMC - PubMed
    1. Chan J.F., Yuan S., Kok K.H. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet (London, England) 2020 doi: 10.1016/s0140-6736(20)30154-9. [published Online First: 2020/01/28] - DOI - PMC - PubMed
    1. Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: adescriptivestudy. Lancet. 2020;(20):30211–30217. pii:S0140- 6736. - PMC - PubMed
    1. Chen N., Zhou M., Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London, England) 2020 doi: 10.1016/s0140-6736(20)30211-7[published. Online First: 2020/02/03] - DOI - PMC - PubMed
    1. General Office of the National Health and Health Commission . fourth edition. 2020. Notice on Issuing a New Coronavirus Pneumonia Prevention and Control Plan.http://www.nhc.gov.cn/jkj/s3577/202002/573340613ab243b3a7f61df260551dd4.... 109.(2020-02-06)[2020-02-14]

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