Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Jun:56:102788.
doi: 10.1016/j.ebiom.2020.102788. Epub 2020 Jun 7.

Release the ballast: Glioblastoma rises above radiation therapy by exporting miR-603 in extracellular vesicles to become treatment-resistant

Affiliations
Comment

Release the ballast: Glioblastoma rises above radiation therapy by exporting miR-603 in extracellular vesicles to become treatment-resistant

Defne Bayik et al. EBioMedicine. 2020 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare no conflict of interest.

Figures

Fig 1
Fig. 1
miR603 suppresses IGF1 and IGF1R translation in radiosensitive, non-cancer stem cells (blue cells) at GBM diagnosis. After radiation therapy (RT), miR603 is exported via extracellular vesicles, resulting in expression of IGF1 and IGF1R, as well as a radioresistant, cancer stem cell phenotype (red cells). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Comment on

References

    1. Marenco-Hillembrand L., Wijesekera O., Suarez-Meade P., Mampre D., Jackson C., Peterson J. Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis. J Neurooncol. 2020 doi: 10.1007/s11060-020-03451-6. https://doi.org/ - DOI - PubMed
    1. Ramakrishnan V., Xu B., Akers J., Nguyen T., Ma J., Dhawan S. Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1- mediated stem cell state in glioblastomas. EBioMedicine. 2020 doi: 10.1016/j.ebiom.2020.102736. https://doi.org/ - DOI - PMC - PubMed
    1. Hegi M.E., Diserens A.C., Gorlia T., Hamou M.F., de Tribolet N., Weller M. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997–1003. - PubMed
    1. Skog J., Wurdinger T., van Rijn S., Meijer D.H., Gainche L., Sena-Esteves M. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10(12):1470–1476. - PMC - PubMed
    1. Figueroa J., Phillips L.M., Shahar T., Hossain A., Gumin J., Kim H. Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587. Cancer Res. 2017;77(21):5808–5819. - PMC - PubMed