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. 2020 Jun 3;12(6):1667.
doi: 10.3390/nu12061667.

Vitamin C in Home Parenteral Nutrition: A Need for Monitoring

Julienne Grillot  1   2 , Sabrina Ait  1 , Charlotte Bergoin  1 , Thomas Couronne  3 , Emilie Blond  2   4 , Catherine Peraldi  5 , Didier Barnoud  1 , Cécile Chambrier  1   5 , Madeleine Lauverjat  5
Affiliations

Vitamin C in Home Parenteral Nutrition: A Need for Monitoring

Julienne Grillot et al. Nutrients. .

Abstract

To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., <25 µmol/L). In univariate analysis, C-reactive protein (CRP) (p = 0.002) and intake of only 125 mg of vitamin C (p = 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (p = 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (p = 0.001) and intake of 125 mg of vitamin C (p < 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (p = 0.008) and presented an inflammatory syndrome (p = 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP.

Keywords: commercial multivitamin preparation; home parenteral nutrition; vitamin C.

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Conflict of interest statement

J.G. received lecture fees from Mylan, Baxter, Pfizer, MSD, Elivie, DDS Assistance, Fresenius Kabi, Nutricia, and Nestlé Health Science France. S.A. received lecture fees from Nestlé Health Science France and Shire. C.B. received lecture fess from Takeda, Shire, Abbvie, Fresenius Kabi, Linde Homecare France, Experf Rhone Alpes, Elivie, Janssen-Cilag, Mayoly Spindler, and MSD. T.C. none. E.B. none. C.P. received lecture fees from Takeda and Geistlich Pharma. D.B. received lecture fees from Baxter, Nutricia, Fresenius Kabi, Shire. C.C. received lecture fees from Aguettant, Baxter, B Braun, Coloplast, Fresenius Kabi, Nutricia, Nestlé Clinical Nutrition, Shire, Zealand. M.L. received lecture fees from Shire, Theradial, Fresenius Kabi, Elivie, LVL Medical and Nutricia.

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