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. 2020 Jun 5;20(1):520.
doi: 10.1186/s12885-020-06972-5.

Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma

Yangli Liu  1 , Ying Zhu  2   3 , Lihong Bai  1 , Fengjia Chen  1 , Jue Wang  4 , Yubiao Guo  5
Affiliations

Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma

Yangli Liu et al. BMC Cancer. .

Abstract

Background: According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Due to its rarity, no study investigating the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC has been reported.

Methods: Sixty eight patients who underwent surgical resection for lung adenosquamous carcinoma in our institute between January 2006 and March 2017 were retrospectively reviewed. Data regarding the clinical features, radiologic findings and prognosis characteristics were collected.

Results: Thirty nine patients of the study cohort were with AC-predominant ASC and 29 with SCC-predominant ASC. There was no significant difference between the two subgroups in age, gender, smoking history, serum carcinoembryonic antigen (CEA) level and T,N classification. Air bronchogram was found more frequently in AC-predominant ASC than in SCC-predominant ASC (P = 0.046). Multivariate analysis identified pathological subtype (P = 0.022) and CT findings of peripheral location (P = 0.009) to be independent prognostic factors.

Conclusions: AC-predominant ASC were more commonly presented with air bronchogram, and were with a better prognosis than SCC-predominant ASC.

Keywords: Lung adenosquamous carcinoma; Pathological subtypes; Prognosis; Surgery resection.

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Conflict of interest statement

All the authors declare no competing interests.

Figures

Fig. 1
Fig. 1
a, b- Representative histological images of AC-predominant ASC of the lung. c, d- Representative histological images of SCC-predominant ASC of the lung
Fig. 2
Fig. 2
a, b- Overall survival (OS) analysis. a OS curves for patients with AC-predominant ASC and SCC-predominant ASC (P < 0.05). b OS curves for patients with peripherally located ASC and centrally located ASC. (p < 0.05)
See this image and copyright information in PMC

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