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. 2020 Jun 5;15(1):144.
doi: 10.1186/s13014-020-01578-4.

The effect of radiotherapy on taste sensation in head and neck cancer patients - a prospective study

Michal Asif  1 , Assaf Moore  2   3 , Noam Yarom  4   5 , Aron Popovtzer  1   6
Affiliations

The effect of radiotherapy on taste sensation in head and neck cancer patients - a prospective study

Michal Asif et al. Radiat Oncol. .

Abstract

Background: One of the main side effects of head and neck (H&N) radiation therapy (RT) is alteration in taste sensation. It causes significant morbidity and has a major effect on quality of life (QoL). The aim of this study was to prospectively define the effect of RT on taste sensation (general, and four basic tastes) and correlate these findings with changes in saliva secretion and QoL questionnaires.

Methods: Patients with H&N cancer treated with RT, in which the oral cavity was expected to receive a mean dose of 30 Gray (Gy). Patients were evaluated by Whole-Saliva Sialometry, validated Taste Strips and European Organization for Research and Treatment of Cancer H&N QoL questionnaires prior to RT (T0), mid-point of radiotherapy dose (T1), at the end of radiotherapy (T2) and 1 (T3), 3 (T4) and 12 months (T5) after completion of treatment course.

Results: Twenty-eight patients were recruited, and 21 patients completed study procedures and were analyzed. Median age was 66 years (range 18-90). The most common tumor site was the oral cavity. The median prescribed radiation dose to the high dose volume was 66 (range 60-70). The median mean and max dose to the oral cavity were 25.1 (range 14-69) and 64.9 (range 30-70), respectively. There was a significant decrease in overall taste sensation between T0 and T1 and T2. With specific tastes, there were significant decreases in sensation of sweet and salty, a trend with bitter and no change with sour. All returned to baseline at T3 and onwards. There was no significant correlation between the max or mean dose to the oral cavity and overall taste sensation or between doses to different areas of the tongue and overall or specific tastes. At T0 there was a significant positive correlation between overall taste sensation and whole-saliva sialometry, and at T1 and T2 there were strong trends. There were significant declines in QoL scores during RT.

Conclusions: We found a significant immediate reduction in taste sensation due to RT in H&N cancer patients with taste recovery 1 month after treatment completion. There were strong trends to a correlation with saliva production that requires further exploration.

Keywords: Head and neck cancer; Radiotherapy; Sialometry; Taste sensation; Xerostomia.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Trends in Taste Sensation Over One Year. The X axis is the evaluation point in time: prior to radiotherapy (T0), mid-point of radiotherapy course (T1), at the end of radiotherapy (T2), and approximately 1,3, and 12 months post radiotherapy (T3, T4 and T5 respectively). Each graph represents a specific taste’s median value (sweet sum = sweet, sour sum = sour, salty sum = salty, bitter sum = bitter) of overall taste sensation (total sum). The Y axis represents the median score in the validated Filter Paper Strips Taste Test. A decline can be clearly seen at the end of the radiotherapy course (T2) and a rapid recovery of taste sensation at T3–4
See this image and copyright information in PMC

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