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Observational Study
. 2021 Jun;52(2):569-574.
doi: 10.1007/s12029-020-00432-w.

Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori

Mônica Pezenatto Dos Santos  1 , Jéssica Nunes Pereira  1 , Roger Willian De Labio  1 , Lilian Carla Carneiro  2 , Jaqueline Correia Pontes  2 , Mônica Santiago Barbosa  2 , Marília De Arruda Cardoso Smith  3 , Spencer Luíz Marques Payão  1 , Lucas Trevizani Rasmussen  4
Affiliations
Observational Study

Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori

Mônica Pezenatto Dos Santos et al. J Gastrointest Cancer. 2021 Jun.

Abstract

Purpose: The aim of this study was to evaluate the expression of miR-125a-5p in patients with dyspeptic symptoms and gastric cancer, correlating them with the development of this cancer and H. pylori.

Methods: Patients were divided in groups according to histopathological analysis (control, gastritis, and cancer groups). Polymerase chain reaction was performed to detect H. pylori and real-time quantitative PCR to determine miR-125a-5p expression.

Results: H. pylori was detected in 44% of the patients, with prevalence in the gastritis and cancer groups. A statistically significant decrease of miR-125a-5p expression was found in the control positive (p = 0.0183*), gastritis positive (p = 0.0380*), and cancer positive (p = 0.0288*) groups when compared with the control negative group.

Conclusion: We suggest that decreased expression of the miRNA-125a-5p associated with the presence of the H. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer.

Keywords: Gastric Cancer; Gastric disease; Helicobacter pylori; miRNA-125a-5p.

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