Does type of immunosupression influence the course of Covid-19 infection?
- PMID: 32504741
- PMCID: PMC7834486
- DOI: 10.1016/j.jinf.2020.05.075
Does type of immunosupression influence the course of Covid-19 infection?
Abstract
Coronavirus disease 19 (Covid-19) is a new emerging virus responsible for pandemic and death. High blood pressure, diabetes, obesity have been described as poor prognosis factors. Few data have been reported in patient with immunocompromised status (solid tumor, hematological malignancy, rheumatoid conditions or organ transplant). We evaluated the characteristics of patients, including the outcome, with immunodepression hospitalized in Besancon University hospital (East of France). We wanted to identify if a type of immunosupression influences the course of Covid-19. In a cohort of 80 patients with immunosupression (42 solid tumors, 20 hematological malignancy and 18 non neoplastic immunosupression), poor outcomes (Intensive care unit hospitalization and or deaths) was frequent (38%) and tended to be more frequent in patients with hematological malignancy.
Keywords: Covid-19; cancer; immunosupression; poor outcomes.
Copyright © 2020 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare no competing financial interest and received no grants related to this study.
Comment on
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How is immunosuppressive status affecting children and adults in SARS-CoV-2 infection? A systematic review.J Infect. 2020 Jul;81(1):e61-e66. doi: 10.1016/j.jinf.2020.04.026. Epub 2020 Apr 23. J Infect. 2020. PMID: 32335173 Free PMC article.
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Impacts of immunosuppression and immunodeficiency on COVID-19: A systematic review and meta-analysis.J Infect. 2020 Aug;81(2):e93-e95. doi: 10.1016/j.jinf.2020.05.017. Epub 2020 May 15. J Infect. 2020. PMID: 32417309 Free PMC article. No abstract available.
References
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- Jerome Hadjadj, Nader Yatim, Laura Barnabei, et al Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. doi.org/10.1101/2020.04.19.20068015 - PMC - PubMed
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