Detrimental effects of metabolic dysfunction-associated fatty liver disease and increased neutrophil-to-lymphocyte ratio on severity of COVID-19

G Targher¹, A Mantovani², C D Byrne³, X-B Wang⁴, H-D Yan⁵, Q-F Sun⁶, K-H Pan⁷, K I Zheng⁸, Y-P Chen⁹, M Eslam¹⁰, J George¹⁰, M-H Zheng¹¹

Affiliations

¹ Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani 1, 37126 Verona, Italy. Electronic address: giovanni.targher@univr.it.
² Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani 1, 37126 Verona, Italy.
³ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
⁴ Department of Critical Care Medicine, Wenzhou Central Hospital, Wenzhou, China.
⁵ Department of Hepatology, Key Laboratory of Diagnosis and Treatment of Digestive System Tumours of Zhejiang Province, Hwamei Hospital, Ningbo No. 2 Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁶ Department of Infectious Diseases, Ruian People's Hospital, Wenzhou, China.
⁷ Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁸ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China.
⁹ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
¹⁰ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, Australia.
¹¹ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn.

PMID: 32505652
PMCID: PMC7270805
DOI: 10.1016/j.diabet.2020.06.001

Detrimental effects of metabolic dysfunction-associated fatty liver disease and increased neutrophil-to-lymphocyte ratio on severity of COVID-19

G Targher et al. Diabetes Metab. 2020 Nov.

. 2020 Nov;46(6):505-507.

doi: 10.1016/j.diabet.2020.06.001. Epub 2020 Jun 4.

Authors

G Targher¹, A Mantovani², C D Byrne³, X-B Wang⁴, H-D Yan⁵, Q-F Sun⁶, K-H Pan⁷, K I Zheng⁸, Y-P Chen⁹, M Eslam¹⁰, J George¹⁰, M-H Zheng¹¹

Affiliations

¹ Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani 1, 37126 Verona, Italy. Electronic address: giovanni.targher@univr.it.
² Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale Stefani 1, 37126 Verona, Italy.
³ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
⁴ Department of Critical Care Medicine, Wenzhou Central Hospital, Wenzhou, China.
⁵ Department of Hepatology, Key Laboratory of Diagnosis and Treatment of Digestive System Tumours of Zhejiang Province, Hwamei Hospital, Ningbo No. 2 Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁶ Department of Infectious Diseases, Ruian People's Hospital, Wenzhou, China.
⁷ Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁸ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China.
⁹ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
¹⁰ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, Australia.
¹¹ Department of Hepatology, MAFLD Research Centre, the First Affiliated Hospital of Wenzhou Medical University, No. 2, Fuxue Lane, Wenzhou 325000, China; Institute of Hepatology, Wenzhou Medical University, Wenzhou, China; Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China. Electronic address: zhengmh@wmu.edu.cn.

PMID: 32505652
PMCID: PMC7270805
DOI: 10.1016/j.diabet.2020.06.001

No abstract available

Keywords: COVID-19; Coronavirus disease 2019; MAFLD; Metabolic associated fatty liver disease.

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Figures

**Fig. 1**
Proportion of severe COVID-19 illness among patients, stratified by presence/absence of metabolic dysfunction-associated fatty liver disease (MAFLD) and values of neutrophil-to-lymphocyte ratio (NLR) at hospital admission.

See this image and copyright information in PMC

References

1. Lagunas-Rangel F.A. Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. J Med Virol. 2020 doi: 10.1002/jmv.25819. [Epub ahead of print] - DOI - PMC - PubMed
1. Eslam M., Newsome P.N., Sarin S.K., Anstee Q.M., Targher G., Romero-Gomez M. A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement. J Hepatol. 2020 doi: 10.1016/j.jhep.2020.03.039. [Epub ahead of print; pii: S0168-8278(20)30201-4] - DOI - PubMed
1. Alkhouri N., Morris-Stiff G., Campbell C., Lopez R., Tamimi T.A., Yerian L. Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease. Liver Int. 2012;32:297–302. - PubMed
1. Peng Y., Li Y., He Y., Wei Q., Xie Q., Zhang L. The role of neutrophil to lymphocyte ratio for the assessment of liver fibrosis and cirrhosis: a systematic review. Expert Rev Gastroenterol Hepatol. 2018;12:503–513. - PubMed
1. Targher G., Mantovani A., Byrne C.D., Wang X.B., Yan H.D., Sun Q.F. Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores. Gut. 2020 doi: 10.1136/gutjnl-2020-321611. [Online ahead of print; gutjnl-2020-321611] - DOI - PubMed

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Detrimental effects of metabolic dysfunction-associated fatty liver disease and increased neutrophil-to-lymphocyte ratio on severity of COVID-19

Affiliations

Detrimental effects of metabolic dysfunction-associated fatty liver disease and increased neutrophil-to-lymphocyte ratio on severity of COVID-19

Authors

Affiliations

Figures

References

Publication types