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Review
. 2020 Jun 6;20(8):30.
doi: 10.1007/s11882-020-00928-2.

Eosinophilic Esophagitis: Existing and Upcoming Therapies in an Age of Emerging Molecular and Personalized Medicine

Ian F Slack  1 , Justin T Schwartz  1 , Vincent A Mukkada  2 , Shawna Hottinger  1 , J Pablo Abonia  3
Affiliations
Review

Eosinophilic Esophagitis: Existing and Upcoming Therapies in an Age of Emerging Molecular and Personalized Medicine

Ian F Slack et al. Curr Allergy Asthma Rep. .

Abstract

Purpose of review: Recent research efforts have spurred great progress in the diagnosis and management of eosinophilic esophagitis (EoE). Nonetheless, challenges remain in addressing disease burden and impairment in the growing EoE population. We highlight work from the Cincinnati Center for Eosinophilic Disorders, the Consortium of Eosinophilic Gastrointestinal Disease Researchers, and others that address these ongoing challenges.

Recent findings: New tools for characterizing EoE disease activity include the EoE Histology Scoring System (EoEHSS), endoscopic alternatives, validated patient-reported outcome (PRO) questionnaires, and investigational biomarkers. These diagnostic and monitoring strategies have been complemented by advances in EoE therapy. Treatment modalities have refined the traditional approaches of dietary elimination, swallowed steroids, and proton pump inhibitors (PPI), and biologics offer promise for future treatment. This review summarizes EoE advances in disease management and newly defined EoE endotypes that may serve as the foundation for EoE-personalized medicine.

Keywords: Diagnosis; Endotype; Eosinophilic esophagitis; Treatment.

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Conflict of interest statement

Conflict of Interest Mrs. Hottinger reports grants from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR; Administrative Core, U54AI117804), outside the submitted work. Dr. Mukkada reports consulting fees from Shire/Takeda, outside the submitted work. The other authors declare no conflicts of interest relevant to this manuscript.

Figures

Fig. 1
Fig. 1
Evolution of EoE diagnosis and management over the past 25 years. EoE, eosinophilic esophagitis; anti-interleukin pathway antibodies; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia
See this image and copyright information in PMC

References

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