From air pollution to cardiovascular diseases: the emerging role of epigenetics

Abstract

The association between air pollution and a wide-ranging spectrum of acute and chronic disorders-including cardiovascular diseases-is widely acknowledged. Exposure to airborne pollutants triggers harmful mechanisms such as oxidative stress and systemic inflammation, which lead to increased incidence of myocardial infarction, arterial hypertension, stroke, and heart failure. Sustained efforts have been made in recent years to discover how environmental exposures affect human health through epigenetic phenomena, such as DNA methylation, histone modifications and non-coding RNA-mediated gene regulation. This review summarizes the current evidences on the relationship between air pollution exposure, epigenetic alterations and cardiovascular impact, in view of present implications and future perspectives.

Keywords: DNA methylation; Histone modification; Ischemic cardiac disease; Myocardial infarction; microRNA.