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Randomized Controlled Trial
. 2021 Feb;110(2):465-472.
doi: 10.1111/apa.15401. Epub 2020 Jun 25.

Neurodevelopmental outcomes of a randomised trial of intact cord resuscitation

Manuela Isacson  1 , Rejina Gurung  2 , Omkar Basnet  2 , Ola Andersson  1   3 , Ashish Kc  4
Affiliations
Randomized Controlled Trial

Neurodevelopmental outcomes of a randomised trial of intact cord resuscitation

Manuela Isacson et al. Acta Paediatr. 2021 Feb.

Abstract

Aim: It has been suggested that intact cord resuscitation can reduce the risk of brain damage. We investigated the effects on neurodevelopment at two years of age.

Methods: This study was performed in Kathmandu, Nepal. In 2016, 231 late preterm and term infants born vaginally and not breathing were randomised to resuscitation with an intact cord or the standard practice of early cord clamping (CC). At two years of age, the World Health Organization's Infant and Young Child Development tool was used to assess the child's neurodevelopment, during telephone interviews with caregivers.

Results: We followed up 138 infants (59.7%) at a mean age of 24.8 ± 0.8 months. A significant difference was seen in the development for age Z-score, between the group resuscitated with an intact umbilical cord and the group resuscitated with early CC. The median (range) scores were 1.0 (0.1-2.1) vs 0.9 (-2.0 to 1.8), respectively (P = .04). There was no difference in the motor, language-cognitive and socio-emotional domains.

Conclusion: Neurodevelopment improvements were observed at two years of age in infants resuscitated with an intact rather than early clamped umbilical cord. No definitive conclusions could be drawn due to protocol violations and a low follow-up rate. More research is needed.

Keywords: clamping; intact cord; neurodevelopment; resuscitation; umbilical cord.

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References

REFERENCES

    1. Transforming Our World: The 2030 Agenda for Sustainable Development A/RES/70/1. Available from. https://sustainabledevelopment.un.org/index.php. Accessed October 22, 2019.
    1. WHO. Global Strategy for Women's, Children's and Adolescent's Health & Every Woman Every Child Initiative. World Health Organization. Available from http://www.who.int/life-course/partners/global-strategy/en/. Accessed 22 October 22, 2019.
    1. Lee ACC, Kozuki N, Blencowe H, et al. Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. Pediatr Res. 2013;74(Suppl 1):50-72.
    1. Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016;388(10063):3027-3035.
    1. Pin TW, Eldridge B, Galea MP. A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol. 2009;13(3):224-234.

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