Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Aug;47(8):6207-6216.
doi: 10.1007/s11033-020-05565-6. Epub 2020 Jun 7.

Synthetic biology in various cellular and molecular fields: applications, limitations, and perspective

Mohsen Safaei  1 , Gholam-Reza Mobini  2 , Ardavan Abiri  3 , Ali Shojaeian  4
Affiliations
Review

Synthetic biology in various cellular and molecular fields: applications, limitations, and perspective

Mohsen Safaei et al. Mol Biol Rep. 2020 Aug.

Abstract

Synthetic biology breakthroughs have facilitated genetic circuit engineering to program cells through novel biological functions, dynamic gene expressions, as well as logic controls. SynBio can also participate in the rapid development of new treatments required for the human lifestyle. Moreover, these technologies are applied in the development of innovative therapeutic, diagnostic, as well as discovery-related methods within a wide range of cellular and molecular applications. In the present review study, SynBio applications in various cellular and molecular fields such as novel strategies for cancer therapy, biosensing, metabolic engineering, protein engineering, and tissue engineering were highlighted and summarized. The major safety and regulatory concerns about synthetic biology will be the environmental release, legal concerns, and risks of the engineered organisms. The final sections focused on limitations to SynBio.

Keywords: Cancer therapy; SynBio applications; Synthetic biology; Tissue engineering.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Nandagopal N, Elowitz MB (2011) Synthetic biology: integrated gene circuits. Science 333(6047):1244–1248 - PubMed - PMC
    1. Schmidt M (2012) Synthetic biology: industrial and environmental applications. Wiley, Weinheim
    1. Gruber AR, Lorenz R, Bernhart SH, Neuböck R, Hofacker IL (2008) The vienna RNA websuite. Nucleic Acids Res 36(suppl_2):W70–W74 - PubMed - PMC
    1. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E (2012) A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816–821 - PubMed - PMC
    1. MacDonald IC, Deans TL (2016) Tools and applications in synthetic biology. Adv Drug Deliv Rev 105:20–34 - PubMed

LinkOut - more resources