Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 Aug;22(4):445-447.
doi: 10.1007/s40272-020-00402-6.

Target Drug Exposure Attainment in Children: How to Get from Better to Best

Robert B Flint  1   2 , Karel Allegaert  3   4   5
Affiliations
Comment

Target Drug Exposure Attainment in Children: How to Get from Better to Best

Robert B Flint et al. Paediatr Drugs. 2020 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Robert B. Flint and Karel Allegaert have no conflicts of interest that are directly relevant to the content of this article.

Comment on

References

    1. van den Anker J, Reed MD, Allegaert K, Kearns GL. Developmental changes in pharmacokinetics and pharmacodynamics. J Clin Pharmacol. 2018;58(Suppl 10):S10–S25. doi: 10.1002/jcph.1284. - DOI - PubMed
    1. Keizer RJ, Ter Heine R, Frymoyer A, Lesko LJ, Mangat R, Goswami S. Model-informed precision dosing at the bedside: scientific challenges and opportunities. CPT Pharmacometr Syst Pharmacol. 2018;7(12):785–787. doi: 10.1002/psp4.12353. - DOI - PMC - PubMed
    1. Hartman SJF, Orriens LB, Zwaag SM, et al. External validation of model-based dosing guidelines for vancomycin, gentamicin and tobramycin in critically ill neonates and children—a pragmatic two-center study. Pediatr Drugs. 2020 doi: 10.1007/s40272-020-00400-8. - DOI - PMC - PubMed
    1. Janssen EJ, Valitalo PA, Allegaert K, de Cock RF, Simons SH, Sherwin CM, et al. Towards rational dosing algorithms for vancomycin in neonates and infants based on population pharmacokinetic modeling. Antimicrob Agents Chemother. 2016;60(2):1013–1021. doi: 10.1128/AAC.01968-15. - DOI - PMC - PubMed
    1. Valitalo PA, van den Anker JN, Allegaert K, de Cock RF, de Hoog M, Simons SH, et al. Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates. J Antimicrob Chemother. 2015;70(7):2074–2077. doi: 10.1093/jac/dkv052. - DOI - PMC - PubMed

LinkOut - more resources