Acute lung injury in patients with COVID-19 infection

doi:10.1002/ctm2.16

. 2020 Jan;10(1):20-27.

doi: 10.1002/ctm2.16. Epub 2020 Mar 31.

Acute lung injury in patients with COVID-19 infection

Liyang Li¹, Qihong Huang¹, Diane C Wang², David H Ingbar³, Xiangdong Wang^{1

4

5

6}

Affiliations

¹ Zhongshan Hospital Institute of Clinical Science, Shanghai Medical School, Fudan University, Shanghai, China.
² Department of Emergency, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
³ Pulmonary, Allergy, Critical Care & Sleep Division, Center for Lung Science and Health, University of Minnesota, Minnesota, USA.
⁴ Jinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
⁵ Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases, Shanghai, China.
⁶ Shanghai Institute of Clinical Bioinformatics, Shanghai, China.

PMID: 32508022
PMCID: PMC7240840
DOI: 10.1002/ctm2.16

Acute lung injury in patients with COVID-19 infection

Liyang Li et al. Clin Transl Med. 2020 Jan.

. 2020 Jan;10(1):20-27.

doi: 10.1002/ctm2.16. Epub 2020 Mar 31.

Authors

Liyang Li¹, Qihong Huang¹, Diane C Wang², David H Ingbar³, Xiangdong Wang^{1

4

5

6}

Affiliations

¹ Zhongshan Hospital Institute of Clinical Science, Shanghai Medical School, Fudan University, Shanghai, China.
² Department of Emergency, Sunshine Coast University Hospital, Birtinya, Queensland, Australia.
³ Pulmonary, Allergy, Critical Care & Sleep Division, Center for Lung Science and Health, University of Minnesota, Minnesota, USA.
⁴ Jinshan Hospital Center for Tumor Diagnosis & Therapy, Jinshan Hospital, Shanghai Medical School, Fudan University, Shanghai, China.
⁵ Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases, Shanghai, China.
⁶ Shanghai Institute of Clinical Bioinformatics, Shanghai, China.

PMID: 32508022
PMCID: PMC7240840
DOI: 10.1002/ctm2.16

Abstract

During the 2020 Spring Festival in China, the outbreak of a novel coronavirus, named COVID-19 by WHO, brought on a worldwide panic. According to the clinical data of infected patients, radiologic evidence of lung edema is common and deserves clinical attention. Lung edema is a manifestation of acute lung injury (ALI) and may progress to hypoxemia and potentially acute respiratory distress syndrome (ARDS). Patients diagnosed with ARDS have poorer prognosis and potentially higher mortality. Although no effective treatment is formally approved for COVID-19 infection, support of ventilation with oxygen therapy and sometimes mechanical ventilation is often required. Treatment with systemic and/or local glucocorticoids might be helpful to alleviate the pulmonary inflammation and edema, which may decrease the development and/or consequences of ARDS. In this article, we focus on the lung edema and ALI of patients with this widely transmitted COVID-19 infection in order to provide clinical indications and potential therapeutic targets for clinicians and researchers.

Keywords: ARDS; COVID-19; lung edema.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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[1] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020. 10.1016/s0140-6736(20)30183-5. - DOI - PMC - PubMed

[2] Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020. 10.1016/s0140-6736(20)30183-5. - DOI - PMC - PubMed

[3] Jun S, Jinjun J, Ling Y, Lijuan H, Chunxue B, Yuanlin S. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med. 2020;9(1):19. - PMC - PubMed

[4] Jun S, Jinjun J, Ling Y, Lijuan H, Chunxue B, Yuanlin S. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Transl Med. 2020;9(1):19. - PMC - PubMed

[5] Zhang L, Huang Q, Wang X. Significance of clinical phenomes of patients with COVID‐19 infection: a learning from 3795 patients in 80 reports. Clin Transl Med. 2020. in press. - PMC - PubMed

[6] Zhang L, Huang Q, Wang X. Significance of clinical phenomes of patients with COVID‐19 infection: a learning from 3795 patients in 80 reports. Clin Transl Med. 2020. in press. - PMC - PubMed

[7] Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E. A novel coronavirus emerging in China ‐ key questions for impact assessment. N Engl J Med. 2020. 10.1056/NEJMp2000929. - DOI - PubMed

[8] Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E. A novel coronavirus emerging in China ‐ key questions for impact assessment. N Engl J Med. 2020. 10.1056/NEJMp2000929. - DOI - PubMed

[9] Michael C, Adam B, Xueyan M, et al. CT imaging features of 2019 novel coronavirus (2019‐nCoV). Radiology. 2020. 10.1148/radiol.2020200230. - DOI - PMC - PubMed

[10] Michael C, Adam B, Xueyan M, et al. CT imaging features of 2019 novel coronavirus (2019‐nCoV). Radiology. 2020. 10.1148/radiol.2020200230. - DOI - PMC - PubMed

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Acute lung injury in patients with COVID-19 infection

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Acute lung injury in patients with COVID-19 infection

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