Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population

doi:10.1155/2020/7982107

. 2020 May 16:2020:7982107.

doi: 10.1155/2020/7982107. eCollection 2020.

Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population

Chaohui Jian¹, Yiting Xu¹, Xiaojing Ma¹, Yun Shen¹, Yufei Wang¹, Yuqian Bao¹

Affiliations

Affiliation

¹ Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.

PMID: 32508918
PMCID: PMC7246413
DOI: 10.1155/2020/7982107

Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population

Chaohui Jian et al. Int J Endocrinol. 2020.

. 2020 May 16:2020:7982107.

doi: 10.1155/2020/7982107. eCollection 2020.

Authors

Chaohui Jian¹, Yiting Xu¹, Xiaojing Ma¹, Yun Shen¹, Yufei Wang¹, Yuqian Bao¹

Affiliation

¹ Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.

PMID: 32508918
PMCID: PMC7246413
DOI: 10.1155/2020/7982107

Abstract

Background: Accumulating evidence has shown that neck circumference (NC) is associated with obesity-related metabolic abnormalities. Nonalcoholic fatty liver disease (NAFLD) is regarded as a liver manifestation of metabolic syndrome. This study aimed to investigate the relationship between NC and liver fat content (LFC) and NAFLD.

Methods: A total of 1698 subjects (577 men and 1121 women) from the Shanghai community were enrolled. All the subjects underwent NC measurement and biochemical measurements. LFC was calculated using the parameters from abdominal ultrasound images. Elevated NC was defined as NC ≥38.5 cm in men and NC ≥34.5 cm in women.

Results: Subjects with NAFLD based on the LFC measurement had higher values of NC, liver enzyme profiles, homoeostasis model assessment-insulin resistance index, and LFC than those without NAFLD (all P < 0.05), irrespective of sex. NC showed an upward trend with the increase of LFC in both men and women (both P < 0.05). An elevated NC could identify 55.22% of men and 50.29% of women with NAFLD based on quantitative ultrasonography. The positive correlation between NC and LFC remained significant even after adjustment for central obesity (both P < 0.05). After adjusting for confounding factors, the risk of NAFLD in subjects with an elevated NC was 1.52-fold higher in men (P=0.036) and 2.31-fold higher in women (P < 0.001).

Conclusions: There was a significant and positive correlation between NC and LFC. The risk of NAFLD increased significantly in subjects with an elevated NC.

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Conflict of interest statement

All authors declare no conflicts of interest.

Figures

**Figure 1**
Neck circumference (NC) levels according to liver fat content (LFC) quartile.

**Figure 2**
The identification of neck circumference (NC) cutoff points for nonalcoholic fatty liver disease (NAFLD) based on quantitative and qualitative ultrasonography.

**Figure 3**
The association of neck circumference (NC) with risks of nonalcoholic fatty liver disease (NAFLD) in different models.

See this image and copyright information in PMC

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References

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[1] Younossi Z. M., Koenig A. B., Abdelatif D., Fazel Y., Henry L., Wymer M. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84. doi: 10.1002/hep.28431. - DOI - PubMed

[2] Younossi Z. M., Koenig A. B., Abdelatif D., Fazel Y., Henry L., Wymer M. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84. doi: 10.1002/hep.28431. - DOI - PubMed

[3] Rinella M. E. Nonalcoholic fatty liver disease. JAMA. 2015;313(22):2263–2273. doi: 10.1001/jama.2015.5370. - DOI - PubMed

[4] Rinella M. E. Nonalcoholic fatty liver disease. JAMA. 2015;313(22):2263–2273. doi: 10.1001/jama.2015.5370. - DOI - PubMed

[5] Li J., Zou B., Yeo Y. H., et al. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology. 2019;4(5):389–398. doi: 10.1016/S2468-1253(19)30039-1. - DOI - PubMed

[6] Li J., Zou B., Yeo Y. H., et al. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999–2019: a systematic review and meta-analysis. The Lancet Gastroenterology & Hepatology. 2019;4(5):389–398. doi: 10.1016/S2468-1253(19)30039-1. - DOI - PubMed

[7] Lonardo A., Ballestri S., Marchesini G., Angulo P., Loria P. Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome. Digestive and Liver Disease. 2015;47(3):181–190. doi: 10.1016/j.dld.2014.09.020. - DOI - PubMed

[8] Lonardo A., Ballestri S., Marchesini G., Angulo P., Loria P. Nonalcoholic fatty liver disease: a precursor of the metabolic syndrome. Digestive and Liver Disease. 2015;47(3):181–190. doi: 10.1016/j.dld.2014.09.020. - DOI - PubMed

[9] Fantin F., Comellato G., Rossi A. P., et al. Relationship between neck circumference, insulin resistance and arterial stiffness in overweight and obese subjects. European Journal of Preventive Cardiology. 2017;24(14):1532–1540. doi: 10.1177/2047487317721655. - DOI - PubMed

[10] Fantin F., Comellato G., Rossi A. P., et al. Relationship between neck circumference, insulin resistance and arterial stiffness in overweight and obese subjects. European Journal of Preventive Cardiology. 2017;24(14):1532–1540. doi: 10.1177/2047487317721655. - DOI - PubMed

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Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population

Affiliation

Neck Circumference is an Effective Supplement for Nonalcoholic Fatty Liver Disease Screening in a Community-Based Population

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