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Review
. 2020 May 18:2020:3834128.
doi: 10.1155/2020/3834128. eCollection 2020.

The Application of Traditional Chinese Medicine Injection on Patients with Acute Coronary Syndrome during the Perioperative Period of Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhaofeng Shi  1   2 , Chen Zhao  3 , Jiayuan Hu  1   2 , Qianqian Dai  1   2 , Manke Guan  1   2 , Changming Zhong  1   2 , Guihua Tian  1   2 , Hongcai Shang  1   2   4
Affiliations
Review

The Application of Traditional Chinese Medicine Injection on Patients with Acute Coronary Syndrome during the Perioperative Period of Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Zhaofeng Shi et al. Evid Based Complement Alternat Med. .

Abstract

Introduction: TCMI with the effect of Liqihuoxue and Yiqihuoxue has been applied as complementary therapies during the perioperative period of PCI for patients with ACS, while the recommended time points and plans of TCMI are still short of the support of evidence-based medicine.

Methods: A systematic review and meta-analysis was conducted to evaluate the clinical efficacy and safety of TCMI on patients with ACS during the perioperative period of PCI. RCTs were searched based on standardized searching rules in seven medical databases from the inception up to August 2019. Two reviewers conducted the study selection, data extraction, and quality analysis independently. Data were analysed with the support of software RevMan and Stata.

Results: A total of 68 articles with 6,043 patients were enrolled. The result of meta-analysis showed that the TCMI combined with western medicine was superior to the western medicine alone on clinical efficiency (before the PCI, before and after the PCI, or overall, P < 0.05), the occurrence of MACE (myocardial infarction and stenocardia: before the PCI, before and after the PCI, or overall, P < 0.05; arrhythmia: before and after the PCI, P < 0.05), and the level of inflammatory factors (hs-CRP: before the PCI, before and after the PCI, or overall, P < 0.05; IL-6: after the PCI, P < 0.05). The TCMI with the effect of Liqihuoxue obtained more support compared with Yiqihuoxue based on the result of meta-analysis.

Conclusions: TCMI with the effect of Liqihuoxue or Yiqihuoxue combined with western medicine generally showed the potential advantage on the treatment of ACS during the perioperative period of PCI. However, the optimal time point of intervention and recommended plan based on the effect still needs more clinical evidence. We consider that the research of precise and standardized application of TCMI will be a promising direction for TCM in the future.

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Conflict of interest statement

All authors declare that there are no conflicts of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
The preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram.
Figure 2
Figure 2
Forest plot of clinical efficiency of TCMI based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue. Note.formula image represents the TCMI with the effect of Liqihuoxue; formula image represents the TCMI with the effect of Yiqihuoxue.
Figure 3
Figure 3
Forest plot of all-cause mortality based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 4
Figure 4
Forest plot of myocardial infarction based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 5
Figure 5
Forest plot of stenocardia based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 6
Figure 6
Forest plot of arrhythmia based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 7
Figure 7
Forest plot of hs-CRP based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 8
Figure 8
Forest plot of IL-6 based on the time point of intervention and the effect of Liqihuoxue or Yiqihuoxue.
Figure 9
Figure 9
The funnel plot of (a) clinical efficiency, (b) MI, (c) stenocardia, and (d) hs-CRP.
See this image and copyright information in PMC

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