Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 16:2020:1012796.
doi: 10.1155/2020/1012796. eCollection 2020.

Association between Timing of Surgical Intervention and Mortality in 15,813 Acute Pancreatitis

Lan Lan  1 , Jiawei Luo  1 , Xiaoyan Yang  1 , Dujiang Yang  2 , Mengjiao Li  1 , Fangwei Chen  3 , Nianyin Zeng  4 , Xiaobo Zhou  5
Affiliations

Association between Timing of Surgical Intervention and Mortality in 15,813 Acute Pancreatitis

Lan Lan et al. Comput Math Methods Med. .

Abstract

Objective: In order to find the quantitative relationship between timing of surgical intervention and risk of death in necrotizing pancreatitis.

Methods: The generalized additive model was applied to quantitate the relationship between surgical time (from the onset of acute pancreatitis to first surgical intervention) and risk of death adjusted for demographic characteristics, infection, organ failure, and important lab indicators extracted from the Electronic Medical Record of West China Hospital of Sichuan University.

Results: We analyzed 1,176 inpatients who had pancreatic drainage, pancreatic debridement, or pancreatectomy experience of 15,813 acute pancreatitis retrospectively. It showed that when surgical time was either modelled alone or adjusted for infection or organ failure, an L-shaped relationship between surgical time and risk of death was presented. When surgical time was within 32.60 days, the risk of death was greater than 50%.

Conclusion: There is an L-shaped relationship between timing of surgical intervention and risk of death in necrotizing pancreatitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Flow diagram of this study.
Figure 2
Figure 2
The relationship between risk of death and five risk factors.
Figure 3
Figure 3
The relationship between risk of death and six risk factors.
Figure 4
Figure 4
The relationship between risk of death and surgical time ((a1) is for all patients, (a2) is for infected patients, and (a3) is for noninfected patients).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.
    Öğütmen Koç D, Bengi G, Gül Ö, Özen Alahdab Y, Altıntaş E, Barutçu S, Bilgiç Y, Bostancı B, Cindoruk M, Çolakoğlu K, Duman D, Ekmen N, Eminler AT, Gökden Y, Günay S, Derviş Hakim G, Irak K, Kacar S, Kalkan İH, Kasap E, Köksal AŞ, Kuran S, Oruç N, Özdoğan O, Özşeker B, Parlak E, Saruç M, Şen İ, Şişman G, Tozlu M, Tunç N, Ünal NG, Ünal HÜ, Yaraş S, Yıldırım AE, Soytürk M, Oğuz D, Sezgin O. Öğütmen Koç D, et al. Turk J Gastroenterol. 2024 Nov 11;35(Suppl 1):S1-S44. doi: 10.5152/tjg.2024.24392. Turk J Gastroenterol. 2024. PMID: 39599919 Free PMC article. Review.

References

    1. Guidelines W. G. I. A. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013;13(4):e1–e15. doi: 10.1016/j.pan.2013.07.063. - DOI - PubMed
    1. Tenner S., Baillie J., DeWitt J., Vege S. S., American College of Gastroenterology American College of Gastroenterology Guideline: Management of Acute Pancreatitis. American Journal of Gastroenterology. 2013;108(9):1400–1415. doi: 10.1038/ajg.2013.218. - DOI - PubMed
    1. UK Working Party on Acute Pancreatitis. UK guidelines for the management of acute pancreatitis. Gut. 2005;54(Supplement 3):iii1–iii9. doi: 10.1136/gut.2004.057026. - DOI - PMC - PubMed
    1. Pezzilli R., Zerbi A., Campra D., et al. Consensus guidelines on severe acute pancreatitis. Digestive and Liver Disease. 2015;47(7):532–543. doi: 10.1016/j.dld.2015.03.022. - DOI - PubMed
    1. Leppäniemi A., Tolonen M., Tarasconi A., et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World Journal of Emergency Surgery. 2019;14(1):p. 27. doi: 10.1186/s13017-019-0247-0. - DOI - PMC - PubMed

LinkOut - more resources