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. 2020 Jul;20(1):61-67.
doi: 10.3892/etm.2020.8572. Epub 2020 Feb 27.

Dynamics of digital ulcers in systemic sclerosis

Carmen Bobeică  1   2 , Alin Laurențiu Tatu  3   4 , Mihaela Crăescu  2   5 , Laura Solovăstru  4   6
Affiliations

Dynamics of digital ulcers in systemic sclerosis

Carmen Bobeică et al. Exp Ther Med. 2020 Jul.

Erratum in

Abstract

Systemic sclerosis (SSc) is a collagenosis with insufficiently known etiopathogenesis, characterized by microvasculopathy and excessive fibrosis in the context of an autoimmune disorder. The incompletely elucidated pathogenesis and limited therapeutic options, disabling aspects, skin lesions and pain determine important functional and psychological deficiencies which affect the quality of life. It is imperative to observe and correlate individual clinical and paraclinical data to optimize disease management. A group of 22 patients diagnosed with SSc, hospitalized in a university clinic in Bucharest was included in an observational study. The evolution of digital ulcers was evaluated as an indicator of vasculopathy and their status and dynamics were correlated with clinical elements reflecting the fibrotic aspect of the disease. The present study shows that the Raynaud phenomenon is almost always present during the course of the disease, but its presence is not always associated with digital ulcers. The existing data in the literature show that fibrosis is subsequent to vasculopathy, but this study did not reveal causality between these two aspects of pathogenesis. The presence of microstomia and digital contracture was identified in the presence of digital ulcers, but also in their absence. The etiopathogenic mechanisms with multiple unknown involved factors open the opportunity to investigate many aspects of SSc for optimal aiming of therapeutic interventions.

Keywords: Raynaud's phenomen; digital ulcers; microangiopaty; microstomia; microvasculopathy; systemic sclerosis.

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Figures

Figure 1
Figure 1
Status of digital ulcers - frequency distribution.
Figure 2
Figure 2
Dynamics of digital ulcers - frequency distribution.
Figure 3
Figure 3
Evolution of digital ulcers - frequency distribution.
Figure 4
Figure 4
Pattern of blood capillary damage - frequency distributions.
Figure 5
Figure 5
Correlation of acroosteolysis with digital ulcers - frequency distributions.
Figure 6
Figure 6
Correlation of microstomia with digital ulcers - frequency distributions.
Figure 7
Figure 7
Correlation between the high degree microstomia and digital ulcers - frequency distribution.
Figure 8
Figure 8
Correlation between digital ulcers and absence of digital contracture - frequency distribution.
Figure 9
Figure 9
Correlation of digital ulcers with presence of digital contracture - frequency distribution.
Figure 10
Figure 10
Correlation of digital ulcers with digital contracture - frequency distribution.
See this image and copyright information in PMC

References

    1. Chihara M, Kurita M, Yoshihara Y, Asahina A, Yanaba K. Clinical significance of serum galectin-9 and soluble CD155 levels in patients with systemic sclerosis. J Immunol Res. 2018;2018(9473243) doi: 10.1155/2018/9473243. - DOI - PMC - PubMed
    1. Cottin V, Brown KK. Interstitial lung disease associated with systemic sclerosis (SSc-ILD) Respir Res. 2019;20(13) doi: 10.1186/s12931-019-0980-7. - DOI - PMC - PubMed
    1. Butt SA, Jeppesen JL, Fuchs C, Mogensen M, Engelhart M, Torp-Pedersen C, Gislason GH, Jacobsen S, Andersson C. Trends in incidence, mortality, and causes of death associated with systemic sclerosis in Denmark between 1995 and 2015: A nationwide cohort study. BMC Rheumatol. 2018;2(36) doi: 10.1186/s41927-018-0043-6. - DOI - PMC - PubMed
    1. Friedrich S, Lüders S, Glimm AM, Werner SG, Schmittat G, Burmester GR, Backhaus M, Riemekasten G, Ohrndorf S. Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis. Arthritis Res Ther. 2019;21(96) doi: 10.1186/s13075-019-1875-1. - DOI - PMC - PubMed
    1. McFarlane IM, Bhamra MS, Kreps A, Iqbal S, Al-Ani F, Saladini-Aponte C, Grant C, Singh S, Awwal K, Koci K, et al. Gastrointestinal manifestations of systemic sclerosis. Rheumatology (Sunnyvale) 2018;8(235) doi: 10.4172/2161-1149.1000235. - DOI - PMC - PubMed