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Review
. 2020 May 15;12(5):1553-1568.
eCollection 2020.

Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review

Renling Li  1 , Peng Li  2 , Wenqun Xing  2 , Huiling Qiu  1
Affiliations
Review

Heterogeneous genomic aberrations in esophageal squamous cell carcinoma: a review

Renling Li et al. Am J Transl Res. .

Abstract

Esophageal cancer (EC) causes hundreds of thousands of deaths a year worldwide, especially the major subtype esophageal squamous cell carcinoma (ESCC). With the advent of next-generation sequencing and the availability of commercial microarrays, abnormities in genetic levels have been revealed in various independent researches. High frequencies of structure variations (SVs), single nucleotide variations (SNVs) and copy-number alterations (CNAs) in ESCCs are uncovered, and ESCC shows high levels of inter- and intratumor heterogeneity, implying diverse evolutionary trajectories. This review tries to explain the pathogenesis of ESCC on the scope of most often mutated genes based on prior studies, hopes to offer some hints for diagnosis and therapy in clinic.

Keywords: ESCC; evolution; genomic alterations; heterogeneity; pathogenesis.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Based on SEER (Surveillance, Epidemiology, and End Results) website, esophagus cancer incidence rates by age at diagnosis in USA from 2012 to 2016.
See this image and copyright information in PMC

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