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. 2020;11(2):143-149.
doi: 10.22088/cjim.11.2.143.

Helicobacter pylori eradication in the management of glaucoma

Shahram Ala  1 , Iradj Maleki  2 , Ali Sanjari Araghi  3 , Adeleh Sahebnasagh  4 , Anahita Shahraki  1
Affiliations

Helicobacter pylori eradication in the management of glaucoma

Shahram Ala et al. Caspian J Intern Med. 2020.

Abstract

Background: To investigate the possibility that the eradication of H pylori infection is associated with a reduction in the risk of glaucoma.

Methods: Sixty-five successive patients with elevated intraocular pressure (IOP) or glaucoma were included in the study. Serum samples from all subjects were analyzed for the presence of H pylori- antibodies using ELISA. Forty patients with positive serologic test were included. Half of the patients enrolled into intervention group and the other half registered as control. Intervention arm was referred to the Gastroenterology Clinic for eradication of H pylori and evaluated for the effect of H pylori regimen eradication on IOP and glaucoma over 2 months of follow-up. The age-matched controls did not receive treatment. Urea breath test was applied to confirm eradication.

Results: There was a significant (p=0.005) reduction in IOP after complete eradication in the intervention group. This value was not significant in control patients (p=0.08). The mean IOP before treatment of glaucoma in the control group was 23.60±2.37 mmHg and after treatment with anti-glaucoma drugs was 14.25±1.48 mmHg on the onset of study, and 13.55±2.01 mmHg after follow up. The mean IOP before treatment of glaucoma in the intervention group was 24.55±3.6 mmHg and after treatment with anti-glaucoma drugs was 15.15±1.8 mmHg, and 14.3±1.6 mmHg after the eradication of H pylori with a drug regimen. However, after the treatment of glaucoma in all patients, the overall comparison of mean IOP differences showed no statistical difference (P=0.65).

Conclusion: H pylori eradication therapy may have a positive effect on the management of glaucoma.

Keywords: Eradication; Helicobacter pylori infection; Intraocular pressure; Management; Open-angle glaucoma.

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Figures

Figure 1
Figure 1
The comparison of IOP differences of all of the patients in intervention and control groups
See this image and copyright information in PMC

References

    1. Kingman S. Glaucoma is second leading cause of blindness globally. Bulletin of the World Health Organization. 2004;82:887–8. - PMC - PubMed
    1. Distelhorst JS, Hughes GM. 2003. Open-angle glaucoma. Am Fam Physician. 2003;67:1937–44. - PubMed
    1. Pache M, Flammer J. A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma. Surv Ophthalmol. 2006;51:179–212. - PubMed
    1. Kulkarni U. 2012. Early detection of primary open angle glaucoma: Is it happening. J Clin Diagn Res. 2012;6:667–70.
    1. Go M. Natural history and epidemiology of helicobacter pylori infection. Aliment Pharmacol Ther. 2002;16:3–15. - PubMed

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