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. 2020 Mar 23;32(1):32-37.
doi: 10.1016/j.joco.2019.07.007. eCollection 2020 Jan-Mar.

Topical Bromfenac Sodium in Femtosecond Laser-Assisted Cataract Surgery

María Camila Aguilar Sierra  1 , Rosa Alvarado-Villacorta  2 , Claudia Palacio Pastrana  1
Affiliations

Topical Bromfenac Sodium in Femtosecond Laser-Assisted Cataract Surgery

María Camila Aguilar Sierra et al. J Curr Ophthalmol. .

Abstract

Purpose: To evaluate the effect of preoperative 0.09% bromfenac ophthalmic solution for the reduction of intraoperative miosis and pain in patients who have undergone femtosecond laser-assisted cataract surgery.

Methods: This prospective randomized clinical study included 65 patients with senile cataracts in the absence of significant ocular comorbidity. The patients received 0.09% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil diameter was measured at the initiation and finalization of femtosecond laser-assisted cataract surgery, and pain quantification was assessed by an analogous pain scale after one day of follow-up.

Results: A total of 65 patients were randomly divided into two groups. Five patients were excluded due to defective coupling with the laser interface. Each of the 60 patients was randomized to receive preoperative topical treatment with either 0.09% bromfenac or 0.1% sodium hyaluronate. Baseline characteristics were similar between groups for age and gender. The mean change in horizontal and vertical pupil diameter from the preoperative to post-femtosecond laser measurements were significantly less in the bromfenac group than in the placebo group (0.43 ± 0.6 vs. 1.71 ± 0.9, P < 0.001 and 0.40 ± 0.6 vs. 1.78 ± 0.9, P < 0.001, respectively). Compared with untreated patients, the quantification of pain one day after the procedure was significantly lower in the 0.09% bromfenac group (46.7% with a score of 3 vs. 50% with a score of 1, P < 0.001, respectively).

Conclusions: The maintenance of pupil dilation and the prevention of miosis were more effective in the 0.09% bromfenac group than in the control group. Likewise, the greater control of postoperative pain represented an additional significant benefit.

Keywords: Bromfenac; Cataract; Femtosecond laser; NSAID; Pupil.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Change in horizontal pupil diameter in patient with either 0.09% bromfenac (study group) or the placebo (control group)
Figure 2
Figure 2
Change in vertical pupil diameter in patient with either 0.09% bromfenac (study group) or the placebo (control group)
Figure 3
Figure 3
Quantification of pain according to the visual analogue scale in patients with and without 0,09% bromfenac before the surgery
See this image and copyright information in PMC

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