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This guideline applies to adult and children patients with primary or recurrent episode of Clostridioides difficile infection (CDI). objective of this guideline is to provide a brief overview of the epidemiology of, and risk factors for development of CDI. Provide guidance regarding which patients should be tested for CDI, summarize merits and limitations of available diagnostic tests, and describe the optimal approach to laboratory diagnosis. Review the most effective treatment strategies for patients with CDI including patients with recurrences or complications.