Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
[Preprint]. 2020 Jun 21:2020.04.04.20047886.
doi: 10.1101/2020.04.04.20047886.

Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load

Antonio Gonçalves, Julie Bertrand, Ruian Ke, Emmanuelle Comets, Xavier de Lamballerie, Denis Malvy, Andrés Pizzorno, Olivier Terrier, Manuel Rosa Calatrava, France Mentré, Patrick Smith, Alan S Perelson, Jérémie Guedj

Timing of antiviral treatment initiation is critical to reduce SARS-CoV-2 viral load

Antonio Gonçalves et al. medRxiv. .

Update in

  • Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load.
    Gonçalves A, Bertrand J, Ke R, Comets E, de Lamballerie X, Malvy D, Pizzorno A, Terrier O, Rosa Calatrava M, Mentré F, Smith P, Perelson AS, Guedj J. Gonçalves A, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):509-514. doi: 10.1002/psp4.12543. Epub 2020 Aug 7. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32558354 Free PMC article.

Abstract

We modeled the viral dynamics of 13 untreated patients infected with SARS-CoV-2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than 2 logs, drug efficacy needs to be greater than 80% if treatment is administered after symptom onset; an efficacy of 50% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 20-70% efficacy. They may help control virus if administered very early, but may not have a major effect in severe patients.

PubMed Disclaimer

Publication types

LinkOut - more resources