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Comment
. 2020 Aug;25(8):722-724.
doi: 10.1016/j.tplants.2020.05.008. Epub 2020 Jun 5.

Prime Editing: Game Changer for Modifying Plant Genomes

Marek Marzec  1 , Goetz Hensel  2
Affiliations
Comment

Prime Editing: Game Changer for Modifying Plant Genomes

Marek Marzec et al. Trends Plant Sci. 2020 Aug.

Abstract

Prime editing, developed by Anzalone et al., brings genome editing to a new level, because this approach allows introduction of all mutation types, including insertions, deletions, and all putative 12 types of base-to-base conversions. Previously tested in human cells, this technique has been adapted for use in plants by Lin et al.

Keywords: CRISPR-Cas9; custom endonucleases; genome editing; targeted mutagenesis.

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  • Search-and-replace genome editing without double-strand breaks or donor DNA.
    Anzalone AV, Randolph PB, Davis JR, Sousa AA, Koblan LW, Levy JM, Chen PJ, Wilson C, Newby GA, Raguram A, Liu DR. Anzalone AV, et al. Nature. 2019 Dec;576(7785):149-157. doi: 10.1038/s41586-019-1711-4. Epub 2019 Oct 21. Nature. 2019. PMID: 31634902 Free PMC article.
  • Prime genome editing in rice and wheat.
    Lin Q, Zong Y, Xue C, Wang S, Jin S, Zhu Z, Wang Y, Anzalone AV, Raguram A, Doman JL, Liu DR, Gao C. Lin Q, et al. Nat Biotechnol. 2020 May;38(5):582-585. doi: 10.1038/s41587-020-0455-x. Epub 2020 Mar 16. Nat Biotechnol. 2020. PMID: 32393904

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