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Review
. 2020 Oct;25(5):101123.
doi: 10.1016/j.siny.2020.101123. Epub 2020 Jun 2.

Prevention of preeclampsia

Marwan Ma'ayeh  1 , Maged M Costantine  2
Affiliations
Review

Prevention of preeclampsia

Marwan Ma'ayeh et al. Semin Fetal Neonatal Med. 2020 Oct.

Abstract

Preeclampsia is an obstetric disorder that affects 3-8% of pregnant women and remains a leading cause of short- and long-term neonatal and maternal morbidity and mortality. Professional societies recommend the use of low dose aspirin to prevent preeclampsia in high-risk women. However, interest in prevention of this disease and better understanding of its pathophysiology have led to growing research on other agents. This review focuses on the main therapeutic agents evaluated or in use for preeclampsia prevention.

Keywords: Aspirin; Esomeprazole; Metformin; Preeclampsia; Pregnancy; Statin.

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Figures

Figure:
Figure:
Pathophysiology of Preeclampsia and Proposed Mechanisms of Actions of Preventive Agents ASA, Aspirin; COX, cyclooxygenase; sEng, soluble endoglin; sFlt1, soluble fms-like tyrosine kinase 1; PGI2, prostaglandin I2 (prostacyclin); PlGF, placental growth factor; TXA2, thromboxane A2; VEGF, vascular endothelial growth factor
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