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Comment
. 2020 Jul;41(7):558-560.
doi: 10.1016/j.it.2020.05.007. Epub 2020 Jun 5.

Where There's Smoke, There's Fire: Inflammation Drives MDS

Gandhar K Datar  1 , Margaret A Goodell  2
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Where There's Smoke, There's Fire: Inflammation Drives MDS

Gandhar K Datar et al. Trends Immunol. 2020 Jul.

Abstract

Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-κB signaling is implicated in inflammatory synergy and MDS progression.

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