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Review
. 2020 Jul;31(7):1384-1386.
doi: 10.1681/ASN.2020050589. Epub 2020 Jun 8.

Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19

Meagan L Adamsick  1 , Ronak G Gandhi  1 , Monique R Bidell  1 , Ramy H Elshaboury  1 , Roby P Bhattacharyya  2 , Arthur Y Kim  2 , Sagar Nigwekar  3 , Eugene P Rhee  3 , Meghan E Sise  4
Affiliations
Review

Remdesivir in Patients with Acute or Chronic Kidney Disease and COVID-19

Meagan L Adamsick et al. J Am Soc Nephrol. 2020 Jul.
No abstract available

Keywords: COVID-19; acute renal failure; antiviral; end-stage renal disease.

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Figures

Figure 1.
Figure 1.
Mechanism of action of remdesivir. Remdesivir triphosphate leads to delayed chain termination after three additional bases have been added.
See this image and copyright information in PMC

References

    1. US Food and Drug Administration : Fact Sheet for Health Care Providers Emergency Use Authorization (EUA) of Remdesivir (GS-5734™), Silver Spring, MD, US Food and Drug Administration, 2020
    1. Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. .: Compassionate use of remdesivir for patients with severe COVID-19 [published online ahead of print April 10, 2020]. N Engl J Med doi:10.1056/NEJMoa2007016 - PMC - PubMed
    1. Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. .: Remdesivir in adults with severe COVID-19: A randomised, double-blind, placebo-controlled, multicentre trial. Lancet 395: 1569–1578, 2020 - PMC - PubMed
    1. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, et al. .: Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 9: eaal3653, 2017 - PMC - PubMed
    1. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. .: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30: 269–271, 2020 - PMC - PubMed

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