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Published Erratum
. 2020 Jun 23;117(25):14612.
doi: 10.1073/pnas.2009107117. Epub 2020 Jun 8.

Correction for Jiao et al., Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

No authors listed
Published Erratum

Correction for Jiao et al., Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 6.
Fig. 6.
Defective macropinocytosis after pitavastatin induces protein and amino acid starvation in PTEN−/− cells. (A) The sensitivity of pitavastatin increases in PTEN−/− cells under serum-free conditions. (Scale bar, 30 μm.) (B) BSA rescues the cytotoxic effects of pitavastatin in mammalian PTEN−/− cells under serum-free conditions. (Scale bar, 30 μm.) (C) Total intracellular BSA in MCF10A and PTEN−/− cells increases with increasing concentrations of BSA in the medium (mean ± SD, n = 3). (D) Leucine (Leu) rescues the cytotoxic effects of pitavastatin on mammalian PTEN−/− cells under serum-free conditions. (Scale bar, 30 μm.) (E) Fluid-phase uptake in Dictyostelium pten− cells in HL5 medium and FM medium. pten− cells in HL5 medium were added with 1 μM pitavastatin; pten− cells in FM medium were added with 4 μM pitavastatin. (Scale bar, 20 μm.) (F) Measurement of fluid-phase uptake in Dictyostelium pten− cells in HL5 medium and FM medium (n = 3 experiments, nonparametric Mann–Whitney–Wilcoxon test, ****P < 0.0001). (G) Dictyostelium pten− cells show resistance to pitavastatin in FM medium containing abundant amino acids. (Scale bar, 20 μm.) (H) Proposed molecular architecture of the mevalonate pathway and macropinocytosis.
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